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Overview

Uniprot IDA0A5G2QWP3
Protein NameAlpha-1,4 glucan phosphorylase
Gene NamePYGB
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
550 VKQENKVKFSAFLEK
816 RNIACSGKFSSDRTI

Function

Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis

Protein Sequence

10 MAKPLTDGER 20 RKQISVRGLA 30 GLGDVAEVRK 40 SFNRHLHFTL 50 VKDRNVATRR 60 DYYLALAHTV 70 RDHLVGRWIR 80 TQQHYYERDP 90 KRIYYLSLEF 100 YMGRTLQNTM 110 VNLGLQNACD 120 EAIYQVRAEV 130 GVGLGGAGRD 140 GRGCLWSADR 150 LVFTLAACFL 160 DSMATLGLAA 170 YGYGIRYEFG 180 IFNQKIVNGW 190 QVEEADDWLR 200 YGNPWEKARP 210 EYTLPVHFYG 220 RVEHSAEGVR 230 WLDTQVVLAM 240 PYDTPVPGYK 250 NDTVNTMRLW 260 SAKAPNDFKL 270 HDFNVGGYIE 280 AVLDRNLAEN 290 ISRVLYPNDN 300 FFEGKELRLK 310 QEYFVVAATL 320 QDVIRRFKSA 330 KFGCRDPVRT 340 SFDTFPDKVA 350 IQLNDTHPAL 360 AIPELMRILV 370 DVEKVDWDKA 380 WDITKKTCAY 390 TNHTVLPEAL 400 ERWPVSMFEK 410 LLPRHLEIIY 420 AINQRHLDHV 430 AALFPGDVDR 440 LRRMSVIEEG 450 DCKRINMAHL 460 CVIGSHAVNG 470 VARIHSEIVK 480 HSVFKDFYEL 490 EPEKFQNKTN 500 GITPRRWLLL 510 CNPGLADTIM 520 ERIGEGFLTD 530 LSQLRKLLPL 540 VNDEALIRDV 550 AQVKQENKVK 560 FSAFLEKEYG 570 VKVNPASMFD 580 VHVKRIHEYK 590 RQLLNCLHVV 600 TLYNRIKKDP 610 GQAFVPRTVM 620 IGGKAAPGYH 630 MAKMIIKLVT 640 SIGDIVNHDP 650 VVGGRLKVIF 660 LENYRVSLAE 670 KVIPAADLSQ 680 QISTAGTEAS 690 GTGNMKFMLN 700 GALTIGTMDG 710 ANVEMAEEAG 720 AENLFIFGLR 730 VEDVEALDRK 740 GYNAREYYER 750 LPELRQAVDQ 760 ISNGFFSPRK 770 PDCFKDLVDM 780 LLNHDRFKVF 790 ADYEAYVACQ 800 ARVDQLYQDP 810 KEWTKKVIRN 820 IACSGKFSSD 830 RTITEYARDI 840 WGVEPSAQQA QAPSLPRD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0008184 glycogen phosphorylase activity
Molecular Function GO:0030170 pyridoxal phosphate binding
Biological Process GO:0005980 glycogen catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.