Overview
| Uniprot ID | A0A5G2QWX7 |
|---|
| Protein Name | Membrane-bound transcription factor site-2 protease |
|---|
| Gene Name | - |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 580 |
PFDCCNKKFAQSTNL |
Function
Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression
Protein Sequence
10
MIPVSLVVVV
20
VGGWTAVYLT
30
DLVLKSSVYF
40
KHSYEDWLEN
50
NGLSISPFHI
60
RWQTAVFNRA
70
FYSWGRRKAR
80
MLYQWFNFGM
90
VFGVIAMFSS
100
FFLLGRTLMQ
110
TLSQMMVDSP
120
SYSSSSSSSS
130
SLSSSSSSSS
140
SSSSSSSSSL
150
HNEQVLQVVV
160
PGINLPVSQL
170
TYFFAAVLIS
180
GVVHEIGHGI
190
AAIREQVRFN
200
GFGIFLFIIY
210
PGAFVDLFTT
220
HLQLISPVQQ
230
LRIFCAENSE
240
MCTDIMELHQ
250
IDVETAPVET
260
VPVETVPMET
270
MAMETVEEYE
280
DISGNWVHGG
290
HHHPPLIALQ
300
PLITSDPNQG
310
DHDQEMILLQ
320
TQEEVVGYYE
330
SEGLLANNLE
340
NQMVVPVNED
350
DCFQQTLASL
360
SASASSSSSS
370
ASSHTRKRSS
380
HGKKPSSKKS
390
CASGKAKAGS
400
SSEERSKKWE
410
QTEVQIKTLE
420
GQFSVTMWSP
430
TDKRDQETGQ
440
TEENPAPDYT
450
EYMKGKKLPP
460
EGIPGVDLSD
470
PKQLAEFTRM
480
KPKKTKEEAP
490
RTIACAHKGC
500
PKMFRDNSAM
510
RKHLHTHGPR
520
VHVCAECGKA
530
FVESSKLKRH
540
QLVHTGEKPF
550
QCTFEGCGKR
560
FSLDFNLRTH
570
VRIHTGDRPY
580
VCPFDCCNKK
590
FAQSTNLKSH
600
ILTHAKNKNG
Q
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0012505 |
endomembrane system |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0000987 |
cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:0004222 |
metalloendopeptidase activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0031293 |
membrane protein intracellular domain proteolysis |
| Biological Process |
GO:1905897 |
regulation of response to endoplasmic reticulum stress |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.