Overview
| Uniprot ID | A0A5G2QXK3 |
|---|
| Protein Name | Small glutamine-rich tetratricopeptide repeat-containing protein alpha |
|---|
| Gene Name | SGTA |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 167 |
CIDPSYSKAYGRMGL |
| 191 |
EAVAYYRKALELDPD |
| 207 |
ETYKSNLKVAELRLR |
Function
Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex. Binds directly to HSC70 and HSP70 and regulates their ATPase activity
Protein Sequence
10
MDNKKRLAYA
20
IIRFLHDQLR
30
HGGLSPDAQE
40
SLEVAIQCLE
50
TAFGVTVEDS
60
DLALPQTLSE
70
IFEAALLSLS
80
TSFPCEVPQD
90
LRSPQQTPPS
100
EEDSAEAERL
110
KTEGNEQMKV
120
ENFEAAVHFY
130
GKAIELNPSN
140
AVYFCNRYAA
150
AYSKLGNYAG
160
AVQDCERAIC
170
IDPSYSKAYG
180
RMGLALSSLN
190
KHTEAVAYYR
200
KALELDPDNE
210
TYKSNLKVAE
220
LRLREAPSPT
230
GGVGSFDIAG
240
LLNNPSFMSM
250
LSQCHRVLRG
260
RPEAFLCSAV
270
FSHWTAHERK
280
RNWTCMLRQI
290
FIIIIFFCLH
300
PSLPFCTLMA
310
PRPLSKQSQQ
320
AVSADQHPSP
330
SNTPPNLVTK
340
VFSKIFPGWG
350
SLLTAVGEAA
360
CGDAVALLPF
370
LQPRPLGLAS
380
GLPALPESTL
390
ATPALTSSLP
400
ATPGPRTRVR
A
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:1904288 |
BAT3 complex binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Biological Process |
GO:0036503 |
ERAD pathway |
| Biological Process |
GO:1904293 |
negative regulation of ERAD pathway |
| Biological Process |
GO:2000059 |
negative regulation of ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:1904294 |
positive regulation of ERAD pathway |
| Biological Process |
GO:2000060 |
positive regulation of ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0071816 |
tail-anchored membrane protein insertion into ER membrane |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.