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Overview

Uniprot IDA0A5G2QY29
Protein NameJunctional adhesion molecule C
Gene NameJAM3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
145 GRAELLGKTSLKIWN

Function

Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis

Protein Sequence

10 MARVATRWCP 20 EAGSWSPTPA 30 APGGLDDIPR 40 GLQWAWQQGQ 50 SVRKTRPALL 60 SALLISFVSH 70 GTGRWDPVLR 80 TSSGCLTGAV 90 NLKSSNRNPV 100 VQEFESVELS 110 CIITDSQTND 120 PRIEWKKIQD 130 EQTSYVFFDN 140 KIQGDLTGRA 150 ELLGKTSLKI 160 WNVTRTDSAL 170 YRCEVVARND 180 RKEIDEIVIE 190 LTVQVKPVPP 200 ACRVPRAVPV 210 GKAATLSCQE 220 GEGYPRPHYS 230 WYRNDVPLPT 240 DSRANPRFRN 250 SSFLLNPETG 260 TLVFNAVHKE 270 DSGQYYCIAS 280 NDAGSARCEE 290 QDMEVYDLNI 300 SGIIGGVLVV 310 LTVLALITAG 320 ICCAYRRGYF 330 INNKQNGESY 340 KNPGKPDGVN 350 YIRTDEEVRS 360 RVRSDLTKDT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005923 bicellular tight junction
Cellular Component GO:0044291 cell-cell contact zone
Cellular Component GO:0030057 desmosome
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0031941 filamentous actin
Cellular Component GO:0005902 microvillus
Cellular Component GO:0033010 paranodal junction
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098636 protein complex involved in cell adhesion
Cellular Component GO:0043220 Schmidt-Lanterman incisure
Molecular Function GO:0098632 cell-cell adhesion mediator activity
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0042803 protein homodimerization activity
Biological Process GO:0034333 adherens junction assembly
Biological Process GO:0001525 angiogenesis
Biological Process GO:0045176 apical protein localization
Biological Process GO:0030154 cell differentiation
Biological Process GO:0016477 cell migration
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0097530 granulocyte migration
Biological Process GO:0097241 hematopoietic stem cell migration to bone marrow
Biological Process GO:0034113 heterotypic cell-cell adhesion
Biological Process GO:0033629 negative regulation of cell adhesion mediated by integrin
Biological Process GO:0033624 negative regulation of integrin activation
Biological Process GO:1902414 protein localization to cell junction
Biological Process GO:0034394 protein localization to cell surface
Biological Process GO:0090022 regulation of neutrophil chemotaxis
Biological Process GO:0007283 spermatogenesis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.