Overview
| Uniprot ID | A0A5G2QYI5 |
|---|
| Protein Name | Mitochondrial import receptor subunit TOM20 homolog |
|---|
| Gene Name | TOMM20 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 63 |
KERAGLSKLPDLKDA |
Function
Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOMM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN. Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases
Protein Sequence
10
MLYIGSFNPH
20
VNSMKQILFL
30
NQFYIWRKRL
40
RLTVTCQGSH
50
RGHSPGRGRK
60
KQKLAKERAG
70
LSKLPDLKDA
80
EAVQKFFLEE
90
IQLGEELLAQ
100
GEYEKGVDHL
110
TNAIAVCGQP
120
QQLLQVLQQT
130
LPPPVFQMLL
140
TKLPTISQRI
150
VSAQSLAEDD
VE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0071944 |
cell periphery |
| Cellular Component |
GO:0140494 |
migrasome |
| Cellular Component |
GO:0044233 |
mitochondria-associated endoplasmic reticulum membrane contact site |
| Cellular Component |
GO:0005742 |
mitochondrial outer membrane translocase complex |
| Cellular Component |
GO:0097225 |
sperm midpiece |
| Molecular Function |
GO:0030943 |
mitochondrion targeting sequence binding |
| Molecular Function |
GO:0015450 |
protein-transporting ATPase activity |
| Molecular Function |
GO:0051082 |
unfolded protein binding |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0030150 |
protein import into mitochondrial matrix |
| Biological Process |
GO:0006626 |
protein targeting to mitochondrion |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.