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Overview

Uniprot ID	A0A5G2QYQ7
Protein Name	Alpha-1,4 glucan phosphorylase
Gene Name	PYGB
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
480	VKQENKVKFSAFLEK
746	RNIACSGKFSSDRTI

Function

Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis

Protein Sequence

10 MAKPLTDGER 20 RKQISVRGLA 30 GLGDVAEVRK 40 SFNRHLHFTL 50 VKDRNVATRR 60 DYYLALAHTV 70 RDHLVGRWIR 80 TQQHYYERDP 90 KRIYYLSLEF 100 YMGRTLQNTM 110 VNLGLQNACD 120 EAIYQLGLDL 130 EELEEMEEDA 140 GLGNGGLGRL 150 AACFLDSMAT 160 LGLAAYGYGI 170 RYEFGIFNQK 180 IVNGWQVEEA 190 DDWLRYGNPW 200 EKARPEYTLP 210 VHFYGRVEHS 220 AEGVRWLDTQ 230 FFEGKELRLK 240 QEYFVVAATL 250 QDVIRRFKSA 260 KFGCRDPVRT 270 SFDTFPDKVA 280 IQLNDTHPAL 290 AIPELMRILV 300 DVEKVDWDKA 310 WDITKKTCAY 320 TNHTVLPEAL 330 ERWPVSMFEK 340 LLPRHLEIIY 350 AINQRHLDHV 360 AALFPGDVDR 370 LRRMSVIEEG 380 DCKRINMAHL 390 CVIGSHAVNG 400 VARIHSEIVK 410 HSVFKDFYEL 420 EPEKFQNKTN 430 GITPRRWLLL 440 CNPGLADTIM 450 ERIGEGFLTD 460 LSQLRKLLPL 470 VNDEALIRDV 480 AQVKQENKVK 490 FSAFLEKEYG 500 VKVNPASMFD 510 VHVKRIHEYK 520 RQLLNCLHVV 530 TLYNRIKKDP 540 GQAFVPRTVM 550 IGGKAAPGYH 560 MAKMIIKLVT 570 SIGDIVNHDP 580 VVGGRLKVIF 590 LENYRVSLAE 600 KVIPAADLSQ 610 QISTAGTEAS 620 GTGNMKFMLN 630 GALTIGTMDG 640 ANVEMAEEAG 650 AENLFIFGLR 660 VEDVEALDRK 670 GYNAREYYER 680 LPELRQAVDQ 690 ISNGFFSPRK 700 PDCFKDLVDM 710 LLNHDRFKVF 720 ADYEAYVACQ 730 ARVDQLYQDP 740 KEWTKKVIRN 750 IACSGKFSSD 760 RTITEYARDI 770 WGVEPSAQQA QAPSLPRD

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0008184	glycogen phosphorylase activity
Molecular Function	GO:0030170	pyridoxal phosphate binding
Biological Process	GO:0005977	glycogen metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.