Search Results
Overview
| Uniprot ID | A0A5G2QYR6 |
|---|---|
| Protein Name | Junctional adhesion molecule A |
| Gene Name | F11R |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 43 | EVRVAENKPAKLSCS |
| 46 | VAENKPAKLSCSYSG |
Function
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation
Protein Sequence
10
MGTKAKVGRK
20
QLLLFTSVIL
30
CSLTLGRGAV
40
YTSEPEVRVA
50
ENKPAKLSCS
60
YSGFSSPRVE
70
WKFTHGDITS
80
LVCYNNKITA
90
SYENRVTFSA
100
SGITFHSVTR
110
KDTGTYTCMV
120
SDEGGNTYGE
130
VTVNLIVLVP
140
PSKPTISVPS
150
SATIGNRAVL
160
TCSEKDGSPP
170
SEYFWFKDGV
180
LMPTEPKSNR
190
AFINSSYSLN
200
PKTGELIFDP
210
VSASDAGDYT
220
CEAQNGYGSP
230
MRSDTVHMEA
240
AELNVGGIVA
250
AVLVTLILLG
260
VLIFGIWFAY
270
SRGYFDRLVY
280
RTSSKKVIYS
290
QPTARRGIQT
300
DLIILGVTLV
310
HASPVSSVLA
320
LLRCYQTLAP
330
DVCSFTGCLI
340
CVLAPTRPPT
FILECCF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005923 | bicellular tight junction |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0005178 | integrin binding |
| Molecular Function | GO:0030165 | PDZ domain binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0031032 | actomyosin structure organization |
| Biological Process | GO:0071260 | cellular response to mechanical stimulus |
| Biological Process | GO:0090557 | establishment of endothelial intestinal barrier |
| Biological Process | GO:0050892 | intestinal absorption |
| Biological Process | GO:0007159 | leukocyte cell-cell adhesion |
| Biological Process | GO:0035683 | memory T cell extravasation |
| Biological Process | GO:0051497 | negative regulation of stress fiber assembly |
| Biological Process | GO:1903142 | positive regulation of establishment of endothelial barrier |
| Biological Process | GO:1901731 | positive regulation of platelet aggregation |
| Biological Process | GO:0035025 | positive regulation of Rho protein signal transduction |
| Biological Process | GO:1902396 | protein localization to bicellular tight junction |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:2000810 | regulation of bicellular tight junction assembly |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:0001817 | regulation of cytokine production |
| Biological Process | GO:0090559 | regulation of membrane permeability |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.