Search Results
Overview
| Uniprot ID | A0A5G2QZ00 |
|---|---|
| Protein Name | Squalene synthase |
| Gene Name | FDFT1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 33 | SSLKTCYKYLNQTSR |
Function
Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway
Protein Sequence
10
VSESHSSSSA
20
SPTAVCVLCP
30
QDSLSSSLKT
40
CYKYLNQTSR
50
SFAAVIQALD
60
GEMRHAVCIF
70
YLVLRALDTL
80
EDDMTISIEK
90
KIPLLHNFHL
100
HLYESDWRFT
110
ESKEKDRQVL
120
EDFPTIALEF
130
RNLAEKYQVV
140
IVDVCRKMGF
150
GMAEFLNKHV
160
TSEREWDKYC
170
HYVAGLVGIG
180
LSRLFSASEL
190
EDPLVGEDTE
200
RANSMGLFLQ
210
KTNIIRDYLE
220
DQQEGREFWP
230
QEVWSKYVKK
240
LGDFAKPENV
250
DLAVQCLNEL
260
VTSTLHHIPD
270
VITYLSRLRN
280
QSIFNFCAIP
290
QVMAIATLAA
300
CYNNQQVFKG
310
VVKIRKGQAV
320
TLMMDATNMP
330
AVKAIIHQYM
340
EEIYHRIPDS
350
DPYSAKTRQI
360
ISTIRTQNLP
370
NCQLISRSHY
380
SPIYLSFVML
390
LAALSWQYLS
400
TLSQVTEDYV
QTGEH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Molecular Function | GO:0055056 | D-glucose transmembrane transporter activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0051996 | squalene synthase [NAD(P)H] activity |
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
| Biological Process | GO:0045338 | farnesyl diphosphate metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.