Search Results
Overview
| Uniprot ID | A0A5G2QZ62 |
|---|---|
| Protein Name | Inosine-5'-monophosphate dehydrogenase |
| Gene Name | IMPDH1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 274 | LASKDSHKQLLCGAA |
| 325 | MVHYIKQKYPHLQVI |
| 470 | FSEGDKVKIAQGVSG |
Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors
Protein Sequence
10
MEEPRAPPAG
20
SGQLPPPLQG
30
GGAADVPECG
40
ARQHPGHETA
50
AQRYSARLLQ
60
AGYEPESMAD
70
YLISGGTGYV
80
PEDGLTAQQL
90
FANADGLTYN
100
DFLILPGFID
110
FTADEVDLTS
120
ALTRKITLKT
130
PLISSPMDTV
140
TEADMAIAMA
150
KFEQGFITDP
160
VVLSPSHTVG
170
DVLEAKMRHG
180
FSGIPITETG
190
TMGSKLVGIV
200
TSRDIDFLAE
210
KDHTTLLSEV
220
MTPRNELVVA
230
PAGVTLKEAN
240
EILQRSKKGK
250
LPIVNDRDEL
260
VAIIARTDLK
270
KNRDYPLASK
280
DSHKQLLCGA
290
AVGTREDDKY
300
RLDLLTQAGA
310
DVIVLDSSQG
320
NSVYQIAMVH
330
YIKQKYPHLQ
340
VIGGNVVTAA
350
QAKNLIDAGV
360
DGLRVGMGCG
370
SICITQEVMA
380
CGRPQGTAVY
390
KVAEYARRFG
400
VPVIADGGIQ
410
TVGHVVKALA
420
LGASTVMMGS
430
LLAATTEAPG
440
EYFFSDGVRL
450
KKYRGMGSLD
460
AMEKSSSSQK
470
RYFSEGDKVK
480
IAQGVSGSIQ
490
DKGSIQKFVP
500
YLIAGIQHGC
510
QDIGARSLSV
520
LRSMMYSGEL
530
KFEKRTMSAQ
540
IEGGVHGLHS
YEKRLY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003938 | IMP dehydrogenase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0000166 | nucleotide binding |
| Biological Process | GO:0006177 | GMP biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.