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Overview

Uniprot IDA0A5G2QZA1
Protein Name14-3-3 protein theta
Gene NameYWHAQ
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
122 KVFYLKMKGDYFRYL
139 VACGDDRKQTIDNSQ
49 NLLSVAYKNVVGGRR
68 VISSIEQKTDTSDKK
80 DKKLQLIKDYREKVE
85 LIKDYREKVESELRS
9 EKTELIQKAKLAEQA

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1

Protein Sequence

10 MEKTELIQKA 20 KLAEQAERYD 30 DMATCMKAVT 40 EQGAELSNEE 50 RNLLSVAYKN 60 VVGGRRSAWR 70 VISSIEQKTD 80 TSDKKLQLIK 90 DYREKVESEL 100 RSICTTVLEL 110 LDKYLIANAT 120 NPESKVFYLK 130 MKGDYFRYLA 140 EVACGDDRKQ 150 TIDNSQGAYQ 160 EAFDISKKEM 170 QPTHPIRLGL 180 ALNFSVFYYE 190 ILNNPELACT 200 LAKTAFDEAI 210 AELDTLNEDS 220 YKDSTLIMQL 230 LRDNLTLWTS 240 DSAGEECDAA EGAEN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.