Search Results
Overview
| Uniprot ID | A0A5G2QZE6 |
|---|---|
| Protein Name | Thioredoxin reductase 1, cytoplasmic |
| Gene Name | TXNRD1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 125 | TNNKGKEKIYSAEKF |
| 131 | EKIYSAEKFLIATGE |
| 399 | DNNKCYAKIVCNIKD |
| 405 | AKIVCNIKDNERVVG |
| 43 | NVGCIPKKLMHQAAL |
Function
Reduces disulfide protein thioredoxin (Trx) to its dithiol-containing form. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. A selenocysteine residue at the C-terminal active site is essential for catalysis. Also has reductase activity on hydrogen peroxide (H2O2)
Protein Sequence
10
LIVLEAARFN
20
KRVMVLDFVT
30
PTPLGTRWGL
40
GGTCVNVGCI
50
PKKLMHQAAL
60
LGQALRDSRN
70
YGWNVEETIK
80
HDWERMTEAV
90
QNHIGSLNWG
100
YRVALREKKV
110
TYENAYGQFV
120
GPHRIKATNN
130
KGKEKIYSAE
140
KFLIATGERP
150
RYLGIPGDKE
160
YCISSDDLFS
170
LPYCPGKTLV
180
VGASYVALEC
190
AGFLAGIGLD
200
VTVMVRSILL
210
RGFDQDMANK
220
IGEHMEEHGV
230
KFIRQFVPIK
240
VEQIEAGMPG
250
RLRVTAKATN
260
SDETIEGEYN
270
TVLLAIGRDA
280
CTRNIGLETV
290
GVEINEKTGK
300
IPVTDEEQTN
310
VPYVYAIGDI
320
LEGKPELTPV
330
AIQAGRLLAQ
340
RLYGGSTVKC
350
DYENVPTTVF
360
TPLEYGACGL
370
SEEKAVEKFG
380
EENIEIYHSY
390
FWPLEWTIPS
400
RDNNKCYAKI
410
VCNIKDNERV
420
VGFHILGPNA
430
GEVTQGFAAA
440
LKCGLTKDQL
450
DSTIGIHPVC
460
AEVAEDCSPG
470
RSSHSLLLCL
FPG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0050137 | NADPH peroxidase activity |
| Molecular Function | GO:0004791 | thioredoxin-disulfide reductase (NADPH) activity |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0006979 | response to oxidative stress |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.