Search Results
Overview
| Uniprot ID | A0A5G2QZQ7 |
|---|---|
| Protein Name | Ran-binding protein 3 |
| Gene Name | RANBP3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 297 | SEEENCEKKEQVAQQ |
| 298 | EEENCEKKEQVAQQA |
Function
Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export
Protein Sequence
10
MGFISGLFFL
20
FNLLQTNVAL
30
FTKNTVLGGK
40
TPIFLFAEKP
50
AIAPPVFVFQ
60
KDKGQKSSAE
70
QKDLSDSGEE
80
PRGEAEAPHH
90
GTGHPESAGE
100
HALELPAPAS
110
ASASTPEAQL
120
LPFPRELAGR
130
SAGGSSPEGG
140
EDSDREDGNY
150
CPPVKRERTS
160
SLTQFPPSQS
170
VSKNNVFMPS
180
TFCEPSAGNS
190
DSEPEEKSSG
200
FRLKPPTLIH
210
GQAPSAGLPS
220
QKPKEQQRSV
230
LRPAVLQAPQ
240
PKALSQTVPS
250
TGTNGVSVPA
260
DCTGAVTLAS
270
PDNPARRSPS
280
DEVPALEEKE
290
SQKNESSNTS
300
EEENCEKKEQ
310
VAQQAFVFGQ
320
NLRDRVKLLP
330
TLTMCVHMVY
340
TGIHTVLPCS
350
SRHPTFMAHL
360
LFSLENSTNS
370
ADAASSKFIF
380
GQNMSERVLS
390
PPKLNEVSSD
400
ANRETIAAES
410
GSESSSQEAT
420
PEKANNVAES
430
LAESAAAYTK
440
ATARKCLLEK
450
VEVITGEEAE
460
SNVLQIQCKL
470
FVFDKTSQSW
480
VERGRGLLRL
490
NDMASTDDGT
500
LQSRLVMRTQ
510
GSLRLILNTK
520
LWAQMQIDKA
530
SEKSIRITAM
540
DTEDQGVKVF
550
LISASSKDTG
560
QLYAALHHRI
570
LALRSRVEQE
580
QEAKTPAPEP
590
GAAPSNEDDS
600
DDDDVLAPSG
610
ATGSGAGDEG
DGQTAGST
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005643 | nuclear pore |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0070412 | R-SMAD binding |
| Biological Process | GO:0006611 | protein export from nucleus |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.