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Overview

Uniprot IDA0A5G2QZU7
Protein NameSodium/potassium-transporting ATPase subunit alpha
Gene NameATP1A1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
375 TSTICSDKTGTLTQN
442 QENLPILKRAVAGDA
466 ELCCGSVKEMRERYT
474 EMRERYTKIVEIPFN
492 KYQLSIHKNPNTAEP
52 SLDELHRKYGTDLSR
524 SSILIHGKEQPLDEE
603 AVPDAVGKCRSAGIK
610 KCRSAGIKVIMVTGD
627 ITAKAIAKGVGIISE
659 QVNPRDAKACVVHGS
696 ARTSPQQKLIIVEGC
771 RLIFDNLKKSIAYTL
841 PRNPKTDKLVNERLI
9 AFKVGRDKYEPAAVS

Function

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis

Protein Sequence

10 MAFKVGRDKY 20 EPAAVSEHGD 30 KKKAKKERDM 40 DELKKEVSMD 50 DHKLSLDELH 60 RKYGTDLSRG 70 LTPARAAEIL 80 ARDGPNALTP 90 PPTTPEWVKF 100 CRQLFGGFSM 110 LLWIGAILCF 120 LAYGIQAATE 130 EEPQNDNLYL 140 GVVLSAVVII 150 TGCFSYYQEA 160 KSSKIMESFK 170 NMVPQQALVI 180 RNGEKMSINA 190 EEVVVGDLVE 200 VKGGDRIPAD 210 LRIISANGCK 220 VDNSSLTGES 230 EPQTRSPDFT 240 NENPLETRNI 250 AFFSTNCVEG 260 TARGIVVYTG 270 DRTVMGRIAT 280 LASGLEGGQT 290 PIAAEIEHFI 300 HIITGVAVFL 310 GVSFFILSLI 320 LEYTWLEAVI 330 FLIGIIVANV 340 PEGLLATVTV 350 CLTLTAKRMA 360 RKNCLVKNLE 370 AVETLGSTST 380 ICSDKTGTLT 390 QNRMTVAHMW 400 FDNQIHEADT 410 TENQSGVSFD 420 KTSATWLALS 430 RIAGLCNRAV 440 FQANQENLPI 450 LKRAVAGDAS 460 ESALLKCIEL 470 CCGSVKEMRE 480 RYTKIVEIPF 490 NSTNKYQLSI 500 HKNPNTAEPR 510 HLLVMKGAPE 520 RILDRCSSIL 530 IHGKEQPLDE 540 ELKDAFQNAY 550 LELGGLGERV 560 LGFCHLFLPD 570 EQFPEGFQFD 580 TDDVNFPLDN 590 LCFVGLISMI 600 DPPRAAVPDA 610 VGKCRSAGIK 620 VIMVTGDHPI 630 TAKAIAKGVG 640 IISEGNETVE 650 DIAARLNIPV 660 SQVNPRDAKA 670 CVVHGSDLKD 680 MTSEQLDDIL 690 KYHTEIVFAR 700 TSPQQKLIIV 710 EGCQRQGAIV 720 AVTGDGVNDS 730 PALKKADIGV 740 AMGIAGSDVS 750 KQAADMILLD 760 DNFASIVTGV 770 EEGRLIFDNL 780 KKSIAYTLTS 790 NIPEITPFLI 800 FIIANIPLPL 810 GTVTILCIDL 820 GTDMVPAISL 830 AYEQAESDIM 840 KRQPRNPKTD 850 KLVNERLISM 860 AYGQIGMIQA 870 LGGFFTYFVI 880 LAENGFLPIH 890 LLGLRVNWDD 900 RWINDVEDSY 910 GQQWTYEQRK 920 IVEFTCHTAF 930 FVSIVVVQWA 940 DLVICKTRRN 950 SVFQQGMKNK 960 ILIFGLFEET 970 ALAAFLSYCP 980 GMGVALRMYP 990 LKPTWWFCAF 1000 PYSLLIFVYD 1010 EVRKLIIRRR 1020 PGGWVEKETY Y

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0090533 cation-transporting ATPase complex
Cellular Component GO:0042470 melanosome
Cellular Component GO:0098797 plasma membrane protein complex
Cellular Component GO:0042383 sarcolemma
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0005391 P-type sodium:potassium-exchanging transporter activity
Molecular Function GO:0030955 potassium ion binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.