Overview
| Uniprot ID | A0A5G2R053 |
|---|
| Protein Name | Galactose mutarotase |
|---|
| Gene Name | GALM |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 259 |
CLKRSKEKQFCARVH |
| 298 |
LDGTLKGKTGAVYPK |
Function
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose
Protein Sequence
10
PCPSPSPVNF
20
CRSRFGGGSS
30
RDLEQLHTPS
40
FPNGFSYKIR
50
VWRPPLGGRD
60
GGKVPAAIRP
70
AESGHHLLGL
80
HQKHPYFGAV
90
VGRVANRIAK
100
GTFTLDGKEY
110
KLAINNGPNS
120
LHGGVRGFDK
130
VLWTPRVLSN
140
GIEFSRVSPD
150
GEEGYPGELK
160
VWVTYTLDGG
170
ELVVNYRAQA
180
SQTTPVNLTN
190
HSYFNLAGQG
200
SPNIYDHEVT
210
IEADAFLPVD
220
ETLIPTGEIA
230
PVQGTAFDLR
240
KPVELGKHLQ
250
EFHINGFDHN
260
FCLKRSKEKQ
270
FCARVHHAGS
280
GRVLEVYTTQ
290
PGIQFYTGNF
300
LDGTLKGKTG
310
AVYPKHSGFC
320
LETQNWPNAV
330
NQPHFPPVLL
340
KPGAGWEPLQ
EPVSCAEIR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Molecular Function |
GO:0004034 |
aldose 1-epimerase activity |
| Molecular Function |
GO:0030246 |
carbohydrate binding |
| Biological Process |
GO:0033499 |
galactose catabolic process via UDP-galactose, Leloir pathway |
| Biological Process |
GO:0006006 |
glucose metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.