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Overview

Uniprot IDA0A5G2R0E5
Protein NameAmine oxidase
Gene NameMAOA
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
501 NRILRLSKELGLETY
523 LVQYVKGKSYPFRGA
637 TNGGQERKFVGGSGQ
773 PAIMGKRKICELYAK
866 EILNALGKVSKKDIW

Function

Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline

Protein Sequence

10 MSAPYSEAST 20 GGGGSGRQGE 30 RASRAQDPVT 40 ARISDPASTL 50 GAATSSTSAW 60 SIHSEWRTAS 70 RPFSSSPSNA 80 SSPDVTHSRS 90 FSAPSRLGSS 100 PGPITDKDIK 110 IGLWGFGARG 120 LSNRIPMSDP 130 RSTTSDGAAP 140 ASNLNTSNPP 150 ESVQGSVPPS 160 ASPQLSPQEP 170 TPPSVSASPG 180 ESVPETLRPN 190 NFLRGPVQGS 200 ISPSMPGFLR 210 ISVPAPPPPT 220 NTPEASVLGL 230 SLLSVQGSPW 240 GSVQVPPTPY 250 NSPRLSVQQS 260 SQASVPDSHR 270 LSEQRSTPLL 280 EPSHEVVRGS 290 APPLVFGLSG 300 SSVQASVPLS 310 DSSIVSIQGS 320 PPPSVLSTPR 330 SSIPGPLTPM 340 NSQVSTQEST 350 QLLGLSYPLT 360 AVEGWAPPPG 370 SPGVPVPGPA 380 PPSAPDSTRV 390 SMEESAPPSG 400 SPRESVEKSA 410 PPLASPTPIP 420 TPRESLGQSM 430 ERQEKANNAG 440 HMVDVVVIGG 450 GISGLSAAKL 460 LNEYGINVLV 470 LEARDRVGGR 480 TYTVRNENVD 490 YVDVGGAYVG 500 PTQNRILRLS 510 KELGLETYKV 520 NVNECLVQYV 530 KGKSYPFRGA 540 FPPVWNPIAY 550 LDYNNLWRTM 560 DDMGKKIPAD 570 APWESPHAEE 580 WDKMTMKDLI 590 DKICWTKTAK 600 RFASLFVNIN 610 VTSEPHEVSA 620 LWFLWYVKQC 630 GGTTRIFSVT 640 NGGQERKFVG 650 GSGQVSERIM 660 HLLGDRVKLR 670 CPVTYVDQSG 680 DNIIVETLNH 690 ELYECQYVIS 700 AIPPTLTAKI 710 HFRPELPSER 720 NQLIQRLPMG 730 AIIKCMMYYK 740 EAFWKKKNYC 750 GCMIIEDEEA 760 PISITLDDTK 770 PDGSLPAIMG 780 KRKICELYAK 790 VLGSQEALHP 800 VHYEEKNWCE 810 EQYSGGCYTA 820 YFPPGIMTQY 830 GRVIRQPVGR 840 IFFAGTETAT 850 QWSGYMEGAV 860 EAGERAAREI 870 LNALGKVSKK 880 DIWLREPESE 890 DVPAFEITRT 900 FWERNLPSVT 910 GLLKIIGFST 920 SVTALWLAVY KFRLLTRS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005741 mitochondrial outer membrane
Molecular Function GO:0097621 monoamine oxidase activity
Molecular Function GO:0008131 primary methylamine oxidase activity
Biological Process GO:0006584 catecholamine metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.