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Overview

Uniprot IDA0A5G2R0J3
Protein NameRho-associated protein kinase
Gene NameROCK2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1144 KKFGWVKKYVIVSSK
1151 KYVIVSSKKILFYDS
1211 ANEGESKKEQEFPVE
519 NNRDLQDKNCLLETA
673 NLLLEAEKRCSILDC
716 KIEQETQKRCLTQND
798 KTQVRELKEECEEKT
809 EEKTKLCKELQQKKQ
815 CKELQQKKQELQDER

Function

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity

Protein Sequence

10 MKAEDYDVVK 20 VIGRGAFGEV 30 QLVRHKASQK 40 VYAMKLLSKF 50 EMIKRSDSAF 60 FWEERDIMAF 70 ANSPWVVQLF 80 CAFQDDKYLY 90 MVMEYMPGGD 100 LVNLMSNYDV 110 PEKWAKFYTA 120 EVVLALDAIH 130 SMGLIHRDVK 140 PDNMLLDKHG 150 HLKLADFGTC 160 MKMDETGMVH 170 CDTAVGTPDY 180 ISPEVLKSQG 190 GDGYYGRECD 200 WWSVGVFLFE 210 MLVGDTPFYA 220 DSLVGTYSKI 230 MDHKNSLCFP 240 EDAEISKHAK 250 NLICAFLTDR 260 EVRLGRNGVE 270 EIKQHPFFKN 280 DQWNWDNIRE 290 TAAPVVPELS 300 SDIDSSNFDD 310 IEDDKGDVET 320 FPIPKAFVGN 330 QLPFIGFTYY 340 RENLLLSDSP 350 SCKENDSIQI 360 RKNEESQEIQ 370 KKLYTLEEHL 380 STEIQAKEEL 390 EQKCKSVNTR 400 LEKVAKELEE 410 EIALRKNVES 420 ALRQLEREKA 430 LLQHKNAEYQ 440 RKADHEADKK 450 RNLENDVNSL 460 KDQLEDLKKR 470 NQNSQISTEK 480 VNQLQRQLDE 490 TNALLRTESD 500 TAARLRKTQA 510 ESSKQIQQLE 520 SNNRDLQDKN 530 CLLETAKLKL 540 EKDFINLQSV 550 LESERRDRTH 560 GSEIINDLQG 570 RISGLEEDLK 580 NGKILLTKVE 590 MEKRQLQERF 600 TDLEKEKNNM 610 EIDMTYQLKV 620 IQQSLEQEEA 630 EHKATKARLA 640 DKNKIYESIE 650 EAKSEAMKEM 660 EKKLLEERTL 670 KQKVENLLLE 680 AEKRCSILDC 690 DLKQSQQKIN 700 ELLKQKDVLN 710 EDVRNLTLKI 720 EQETQKRCLT 730 QNDLKMQTQQ 740 VNTLKMSEKQ 750 LKQENNHLME 760 MKMSLEKQNA 770 ELRKERQDAD 780 GQMKELQDQL 790 EAEQYFSTLY 800 KTQVRELKEE 810 CEEKTKLCKE 820 LQQKKQELQD 830 ERDSLAAQLE 840 ITLTKADSEQ 850 LARSIAEEQY 860 SDLEKEKIMK 870 ELEIKEMMAR 880 HKQELTEKDT 890 TIASLEETNR 900 TLTSDVANLA 910 NEKEELNNKL 920 KDAQEQLSRL 930 KDEEISAAAI 940 KAQFEKQLLT 950 ERTLKTQAVN 960 KLAEIMNRKE 970 PVKRGNDTDM 980 RRKEKENRKL 990 HMELKSEREK 1000 LTQQMIKYQK 1010 ELNEMQAQIA 1020 EESQIRIELQ 1030 MTLDSKDSDI 1040 EQLRSQLQAL 1050 HIGLDSSSIG 1060 SGPGDAEADD 1070 GFPVHITQSH 1080 TMESMSFTYQ 1090 RSSTSLNIAT 1100 KPSSSHMLLD 1110 SDSDSEEESV 1120 PYLPISSEPN 1130 ESRLEGWLSL 1140 PVRNNTKKFG 1150 WVKKYVIVSS 1160 KKILFYDSEQ 1170 DKEQSNPYMV 1180 LDIDKLFHVR 1190 PVTQTDVYRA 1200 DAKEIPRIFQ 1210 ILYANEGESK 1220 KEQEFPVEPV 1230 GEKSNCICHK 1240 GHEFIPTLYH 1250 FPTNCEACMK 1260 PLWHMFKPPP 1270 ALECRRCHIK 1280 CHKDHMDKKE 1290 EIIAPCKVYY 1300 DISSAKNLLL 1310 LANSTEEQQK 1320 WVSRLVKKIP 1330 KKPPAPDPFA 1340 RSSPRTSMKI 1350 QQNQSIRRPS 1360 RQLAANKPSS GPALRIILH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0106310 protein serine kinase activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
Molecular Function GO:0031267 small GTPase binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0010825 positive regulation of centrosome duplication
Biological Process GO:0032956 regulation of actin cytoskeleton organization
Biological Process GO:0007266 Rho protein signal transduction
Biological Process GO:0048511 rhythmic process
Biological Process GO:0006939 smooth muscle contraction

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.