Overview
| Uniprot ID | A0A5G2R0Q7 |
|---|
| Protein Name | Small ubiquitin-related modifier |
|---|
| Gene Name | SUMO1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 23 |
KKEGEYIKLKVIGQD |
| 25 |
EGEYIKLKVIGQDSS |
| 48 |
TTHLKKLKESYCQRQ |
Function
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3
Protein Sequence
10
LFFQEAKPST
20
EDLGDKKEGE
30
YIKLKVIGQD
40
SSEIHFKVKM
50
TTHLKKLKES
60
YCQRQGVPMN
70
SLRFLFEGQR
80
IADNHTPKEL
90
GMEEEDVIEV
100
YQEQTGGHST
V
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0031965 |
nuclear membrane |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0097165 |
nuclear stress granule |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0016605 |
PML body |
| Molecular Function |
GO:0015459 |
potassium channel regulator activity |
| Molecular Function |
GO:0031386 |
protein tag activity |
| Molecular Function |
GO:0044388 |
small protein activating enzyme binding |
| Molecular Function |
GO:0031625 |
ubiquitin protein ligase binding |
| Molecular Function |
GO:1990381 |
ubiquitin-specific protease binding |
| Biological Process |
GO:0071276 |
cellular response to cadmium ion |
| Biological Process |
GO:0034605 |
cellular response to heat |
| Biological Process |
GO:0045759 |
negative regulation of action potential |
| Biological Process |
GO:0042308 |
negative regulation of protein import into nucleus |
| Biological Process |
GO:0060633 |
negative regulation of transcription initiation by RNA polymerase II |
| Biological Process |
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0031334 |
positive regulation of protein-containing complex assembly |
| Biological Process |
GO:0050821 |
protein stabilization |
| Biological Process |
GO:0016925 |
protein sumoylation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.