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Overview

Uniprot IDA0A5G2R0R1
Protein NameAfadin
Gene NameAFDN
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1791 QGHEVSSKVKASRRL
663 SPAERTHKVIAIVNK

Function

Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions

Protein Sequence

10 MSAGARDEER 20 RKLADIIQHW 30 NANRLDLFEI 40 SQPTEDLEFH 50 GVMRFYFQDK 60 AAGNFATKCI 70 RVSSTATTQD 80 VIETLAEKFR 90 PDMRMLSSPK 100 YSLYEVHVSG 110 EERRLDIDEK 120 PLVVQLNWNK 130 DDREGRFVLK 140 NENDAAPPKK 150 AQSNGPEKQE 160 KEGVIQNFKR 170 TLSKKEKKEK 180 KKREKEAMRQ 190 ASDKDDRPFH 200 GEDTENSRLA 210 AEVYKDMPET 220 SFTRTISNPE 230 VVMKRRRQQK 240 LEKRMQEFRS 250 SDGRPDSGGT 260 LRIYADSLKP 270 NIPYKTILLS 280 TTDPADFAVA 290 EALEKYGLEK 300 ENPKDYCIAR 310 VMLPPGAQHS 320 DEKGAKEIIL 330 DDDECPLQIF 340 REWPGDKGML 350 VFQLKRRPPE 360 HIPKKSKKHA 370 EGKPPKGKER 380 PDGSGYGSAL 390 PPEKLPYLVE 400 LSPGRRGHFA 410 YYSYHPHEDG 420 SDSRDKPKLY 430 RLQLSVTEVG 440 TEKFDDSSIQ 450 LFGSGIQPHH 460 CDLTNMDGVV 470 TVTPRSVDAE 480 TYVEGQRISE 490 TTMLQSGVKV 500 QFGASHVFKF 510 VDPSQDHALA 520 KRPGDGGLAV 530 KGPRHKPGIV 540 QETAFDLGGD 550 VHGGTAVASS 560 KGSARPDGDR 570 APSASSSAER 580 GMVKPMVRME 590 PPQEPRRQDT 600 RPQDAAGPEL 610 TLPASIEFRE 620 SAEDSFLSAI 630 INYTNSSTVH 640 FKLSPTYVLY 650 MACRHVLSSQ 660 YRPDVSPAER 670 THKVIAIVNK 680 MVSMMDGVIQ 690 KQKNIAGALA 700 FWMANASELL 710 NFIKQDRDLS 720 RITLDAQDVL 730 AHLVQMAFKY 740 LVHCLQSELN 750 NYMPAFLDDP 760 EENSLQRPKI 770 EDVLHTLTGA 780 MSLLRRCRVN 790 AALTIQLFSQ 800 LFHFINMWLF 810 NRLLTDPESG 820 LCSHYWGAIV 830 RQQLGHVEAW 840 AEKQGLELAA 850 DCHLSRVVQA 860 TTLLTMDKYA 870 PEDAAGINST 880 CFKLNSLQLQ 890 ALLHNYHCAP 900 DEPLVPPDLI 910 ESVVAVAENT 920 ADELARSDGR 930 EVRLEEDPDL 940 QLPFLLPEDG 950 YSCDVVRNIP 960 NGLQEFLDPL 970 CQRGFCRLTP 980 QPRSPGSWTI 990 HFEGAEYESR 1000 LARESTELAQ 1010 PLRKEPEVIT 1020 VTLKKQNGMG 1030 LSIVAAKGAG 1040 QDKLGIYVKS 1050 VVRGGAADVD 1060 GRLAAGDQLL 1070 SVDGRSLVGL 1080 SQERAAELMT 1090 RTSSVVTLEV 1100 AKQGAIYHGL 1110 ATLLNQPSPM 1120 MQRISDRRGS 1130 GKPRPKSEGF 1140 ELYNNSAQNG 1150 SPESPPLPWA 1160 EYSEPKKLPG 1170 DERLTKNRAD 1180 HRSSPNVANQ 1190 PPSPGGKGAH 1200 AAGTAAKITS 1210 VSTGNLCTEE 1220 QTPPPGTEAY 1230 PIPTQAYPRE 1240 YFTFPASRSQ 1250 DRVVPPQSQW 1260 PSYEEKPHAD 1270 SSHSSLAVQR 1280 VTRSQEELRE 1290 DAGAYPLHRM 1300 EAVMDRKSDS 1310 DMWVAQSSSM 1320 GSSASSQEHL 1330 DPSSKAGTPA 1340 STLTKSGPGR 1350 WKTPAVLQPA 1360 PGPQPLRTDL 1370 PTHYAGDVDG 1380 VPVDLPLPPP 1390 PAAAGQGLAG 1400 GQGAAERKKR 1410 EEQQRWYEKE 1420 KARLEEERER 1430 KRREQERKLG 1440 QMRSQALLPA 1450 PLSPGATKPA 1460 APGPQDTVIR 1470 ELQPQQQPRT 1480 IERRDLQYIT 1490 VSREELSAGD 1500 SLSPDPWKRD 1510 AREKLEKQQQ 1520 MHVVDLLSRE 1530 IHELQSKAER 1540 SAEESGRLRK 1550 LMLEWQFQKR 1560 LQESKQKDED 1570 DDEEEDDDVD 1580 TMLIMQRLEA 1590 ERRARQTAVP 1600 AISVLDLLQD 1610 EERRRQQQLE 1620 EMRQREAEER 1630 ARHEEERRRQ 1640 EEERLKREAE 1650 EKRRQEEGYY 1660 SRLEAERRRQ 1670 HEEAERRLLE 1680 PEEPGLGRPP 1690 LPRGYEPPGP 1700 APPPPPQRAA 1710 SYLQAQVLSP 1720 DSLYTAKFVA 1730 YDDDDEEEDG 1740 PAGPASYMGS 1750 TGTLMGAHDG 1760 SRDPRETLSK 1770 SQDADVPGGP 1780 ESLTFRERQR 1790 LFSQGHEVSS 1800 KVKASRRLTE LENELNTK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0005737 cytoplasm
Biological Process GO:0007155 cell adhesion
Biological Process GO:0030154 cell differentiation
Biological Process GO:0034330 cell junction organization
Biological Process GO:0007165 signal transduction

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.