Search Results
Overview
| Uniprot ID | A0A5G2R118 |
|---|---|
| Protein Name | Sorting nexin-17 |
| Gene Name | SNX17 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 434 | TMVKLSSKLSAVSLR |
Function
Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P))
Protein Sequence
10
MHFSIPETES
20
RSGDSGGSAY
30
VAYNIHVNGV
40
LHCRVRYSQL
50
LGLHEQLRKE
60
YGANVLPAFP
70
PKKLFSLTPA
80
EVEQRREQLE
90
KYMQAVRQDP
100
LLGSSETFNS
110
FLRRAQQETQ
120
QVPTEEVSLE
130
VLLSNGQKVL
140
VNVLTSDQTE
150
DVLEAVAAKL
160
DLPDDLIGYF
170
SLFLVREKED
180
GAFSFVRKLQ
190
EFELPYVSVT
200
SLRSQEYKIV
210
LRKSYWDSAY
220
DDDVMENRVG
230
LNLLYAQTVS
240
DIERGWILVT
250
KQHRQLKSLQ
260
EKVSKKEFLR
270
LAQTLRHYGY
280
LRFDACVADF
290
PEKDCPVVVS
300
AGNSELSLQL
310
RLPGQQLREG
320
SFRVTRMRCW
330
RVTSSVPLPS
340
GGTSSPGRGR
350
GEVRLELAFE
360
YLMSKDRLQW
370
VTITSPQAIM
380
MSICLQSMVD
390
ELMVKKSGGS
400
IRKMLRRRVG
410
GTLRRSDSQQ
420
AVKSPPLLES
430
PDASRDTMVK
440
LSSKLSAVSL
450
RGIGTPSTDA
460
SASDVHGNFA
FEGIGDEDL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0050750 | low-density lipoprotein particle receptor binding |
| Molecular Function | GO:0035091 | phosphatidylinositol binding |
| Biological Process | GO:0032456 | endocytic recycling |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.