Overview
| Uniprot ID | A0A5G2R1N9 |
|---|
| Protein Name | Galactose mutarotase |
|---|
| Gene Name | GALM |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 228 |
CLKRSKEKQFCARVH |
| 267 |
LDGTLKGKTGAVYPK |
Function
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose
Protein Sequence
10
THLRVDIISW
20
GCTITALEVK
30
DRQGRASDVV
40
LGFAELKEYL
50
QKHPYFGAVV
60
GRVANRIAKG
70
TFTLDGKEYK
80
LAINNGPNSL
90
HGGVRGFDKV
100
LWTPRVLSNG
110
IEFSRVSPDG
120
EEGYPGELKV
130
WVTYTLDGGE
140
LVVNYRAQAS
150
QTTPVNLTNH
160
SYFNLAGQGS
170
PNIYDHEVTI
180
EADAFLPVDE
190
TLIPTGEIAP
200
VQGTAFDLRK
210
PVELGKHLQE
220
FHINGFDHNF
230
CLKRSKEKQF
240
CARVHHAGSG
250
RVLEVYTTQP
260
GIQFYTGNFL
270
DGTLKGKTGA
280
VYPKHSGFCL
290
ETQNWPNAVN
300
QPHFPPVLLK
310
PGEEYNHTTW
FVFSVA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Molecular Function |
GO:0004034 |
aldose 1-epimerase activity |
| Molecular Function |
GO:0030246 |
carbohydrate binding |
| Biological Process |
GO:0006012 |
galactose metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.