Search Results
Overview
| Uniprot ID | A0A5G2R1P5 |
|---|---|
| Protein Name | Progranulin |
| Gene Name | GRN |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 135 | QHLGVPCKTKAQCPP |
| 480 | KGHTCVGKGHCKRKK |
| 565 | VKARTCEKEEDSALP |
Function
Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8
Protein Sequence
10
MCSGQHLCSR
20
VYTRRKLNLR
30
PHTFLPAWMG
40
YSWGDSGSLG
50
AGAWGWGSDW
60
LQREGPSELK
70
LVAKSLLLFC
80
RWTMWTLVSW
90
VALVTGLVAG
100
TQCPDGQLCP
110
VACCLDPGGA
120
SYSCCNPVPD
130
KWPKALSQHL
140
GVPCKTKAQC
150
PPGHSCILTT
160
NETSNCCPFP
170
EAVSCRDGLH
180
CCPQGFHCSA
190
DGWSCLRRPD
200
TKPSDDILCP
210
NSQFHCPNSS
220
TCCTMLDGSW
230
GCCPMPQASC
240
CGDKVHCCPH
250
GTSCDLAHSR
260
CLTVTNTHPM
270
AKIPSQETIK
280
TAVQCPDAES
290
QCHNNSTCCK
300
LSSGKYGCCP
310
LPNATCCSDH
320
IHCCPHGFVC
330
DPVKKKCFSK
340
ENEAIDFFTK
350
LPAHSVQEVK
360
CDTEVSCPDD
370
YTCCRLQSGK
380
WGCCPFVQAV
390
CCNDHVHCCP
400
TGYQCNIEKG
410
TCDLETQWVP
420
WKEKIPASLS
430
RPDLLAMERD
440
VPCDNVSSCP
450
SSSTCCPVTP
460
GEWGCCPAPE
470
AVCCSDHQYC
480
CPKGHTCVGK
490
GHCKRKKDMV
500
TGLNKMPTRR
510
ASASQPGNTT
520
GCDQHTSCPV
530
GQTCCPSLSK
540
GWACCQLPHA
550
VCCEDRQHCC
560
PAGYTCNVKA
570
RTCEKEEDSA
580
LPATHLARVG
590
DVACGERRFC
600
HNNYTCCRDS
610
LGGWACCPYR
620
QGICCADGRH
630
CCPAGFRCGA
640
RGTKCLHKEA
650
LRWDAPLRDP
APRQLL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0150053 | cerebellar climbing fiber to Purkinje cell synapse |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005770 | late endosome |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Molecular Function | GO:0005125 | cytokine activity |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Biological Process | GO:0002265 | astrocyte activation involved in immune response |
| Biological Process | GO:0007042 | lysosomal lumen acidification |
| Biological Process | GO:0007041 | lysosomal transport |
| Biological Process | GO:0099558 | maintenance of synapse structure |
| Biological Process | GO:0002282 | microglial cell activation involved in immune response |
| Biological Process | GO:1903979 | negative regulation of microglial cell activation |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:1902564 | negative regulation of neutrophil activation |
| Biological Process | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:0048680 | positive regulation of axon regeneration |
| Biological Process | GO:1900426 | positive regulation of defense response to bacterium |
| Biological Process | GO:0010595 | positive regulation of endothelial cell migration |
| Biological Process | GO:0050679 | positive regulation of epithelial cell proliferation |
| Biological Process | GO:0106016 | positive regulation of inflammatory response to wounding |
| Biological Process | GO:1905673 | positive regulation of lysosome organization |
| Biological Process | GO:0043525 | positive regulation of neuron apoptotic process |
| Biological Process | GO:1903334 | positive regulation of protein folding |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0050727 | regulation of inflammatory response |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.