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Overview

Uniprot ID	A0A5G2R1Q1
Protein Name	Cation-independent mannose-6-phosphate receptor
Gene Name	IGF2R
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1181	EGDNCSVKDPRHGNL
120	KDIFKAKKEVPCYVF
1215	YYFRVCGKLSSDVCP
1228	CPTSDRSKVISSCQE
1777	SLSKSTFKVTRDSRT
1935	VTFEWKTKVVCPPKK
1999	DRASVCKKNPSGNVQ
253	TLPKLTAKSNCRYEV
335	DAAVCQVKKADSTQA

Function

Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4

Protein Sequence

10 MVILTVDTKN 20 NRLYKISICG 30 NVAVAPCGTS 40 SAVCMQDLKT 50 NSFHSVGDSV 60 LKSASRSLLE 70 FNTTVSCGQQ 80 SANHRIQSSI 90 TFLCGKTLGT 100 PEFVTATDCV 110 HYFEWRTTAA 120 CKKDIFKAKK 130 EVPCYVFDRE 140 LKKRDLNPLI 150 KVGGAYLVDD 160 SDPDASLFIN 170 VCRDIDTLRD 180 RAPQLRACPL 190 GTAACLVRGD 200 WAFDVGRPRE 210 GLQLLSNDRL 220 VLSYVNEEPA 230 PPDFCDGHSP 240 AVTITFVCPS 250 ERREGTLPKL 260 TAKSNCRYEV 270 EWVTEYACPR 280 DYLESRNCFL 290 SSEQHDITID 300 LQPLSRVGDA 310 PYTCEGEEYV 320 FSLSVCGGAE 330 TPVCNEKDAA 340 VCQVKKADST 350 QAKVAGRLQN 360 QTLRYSDGDL 370 TLIYFGGDEC 380 SSGFQRMSVI 390 NFECNKTAGN 400 NGKGAPVFTG 410 EVDCTYFFTW 420 DTRYACVEEK 430 EALLCGVADG 440 RQRFDLSALA 450 RHSELEQNWE 460 AVDGSQRGAE 470 KKHFFINICR 480 RVLQEGQARG 490 CPEDAAACAV 500 DESGSKNLGK 510 FISSPTREKG 520 NIQLSYSDGD 530 ECGGGKRINT 540 NITLICKPGD 550 LESAPVLRTS 560 RADGCFYEFE 570 WYTAAACVLS 580 RTEGDNCTVF 590 DAQAGFSFDL 600 SPLTKTNGAY 610 KVETEKYEFY 620 INVCGAVSAS 630 ACQPDSGACQ 640 VSKSDKKSWN 650 LGRSNAKLSY 660 YDGMIQLNYH 670 DGTPYNNERR 680 TPRATLITFL 690 CDRDAGVGLP 700 EYQEEDNSTY 710 NFRWYTSYAC 720 PEEPLECVVT 730 DPSTLEQYDL 740 SSLAKSEGGR 750 GGNWYALDSA 760 GPHSTWRKYY 770 INVCRPLNPV 780 PGCDRYASAC 790 QMKYESHQGS 800 FSETVSISNL 810 GVAKAGPVVE 820 NSGSLVLEYV 830 NGSACTTSDG 840 RRTTYTTRIH 850 LVCSRGSLNT 860 HPIFSLSWEC 870 VVSFLWNTEA 880 ACPVRVTTDT 890 DQACSIRDPN 900 SGYVFDLNPL 910 NRSQGYVLTG 920 IGKTFVFNVC 930 GTMPICGTLD 940 GKLASGCEAE 950 TETKELKNLR 960 PGRLVGLEKI 970 LQLSPEGFIT 980 LTYTGLPSHP 990 KGPADAFIIR 1000 FVCNGDLYPG 1010 VPKFLHRDID 1020 SRLGIWNTFF 1030 DFETALACVP 1040 SPVDCLVTDP 1050 EGNEYDLSGL 1060 SRVKKPWTAV 1070 DTTSDGKKRT 1080 FYLSVCNPLP 1090 YIPGCHGSMV 1100 GSCLVSEDKS 1110 LNLGVVQVSP 1120 QVAANGSLSV 1130 VYVNGDTCKD 1140 QRYSTRVILE 1150 CAHTAGSPTF 1160 QLLDDCEYVF 1170 VWRTVEACPV 1180 VRVEGDNCSV 1190 KDPRHGNLYD 1200 LKPLALNDTV 1210 VSAGEYTYYF 1220 RVCGKLSSDV 1230 CPTSDRSKVI 1240 SSCQEKRGPQ 1250 GFQKVAGLLT 1260 QKLTYENGVL 1270 KMNYTGGDTC 1280 HKVYQRSTTI 1290 FFYCDRSTQA 1300 PVFLQETSDC 1310 SYLFEWRTQY 1320 ACPPFDLTEC 1330 SFKDAAGNTF 1340 DLSSLARYSD 1350 NWEAVTRTGA 1360 TEHYLINVCK 1370 SLAPQAGSEP 1380 CPPEAAVCLL 1390 GGAKPVNLGR 1400 VRDGPQWKDG 1410 ATLLKYVDGD 1420 PCPDRIRKKS 1430 TTIRFACRES 1440 QVSSRPMFIS 1450 AVEDCEYTFS 1460 WPTAAACPVK 1470 SNVHDNCQVT 1480 NPVTGHLFDL 1490 SSLSGRAGYT 1500 AAYSEKGLVY 1510 ISVCGDNENC 1520 APGVGACFGQ 1530 TRISVGKANK 1540 RLTYEDQVLR 1550 LVYKNGSPCP 1560 SKTGLTYTSV 1570 ISFVCRPEAG 1580 PTDKPVLISL 1590 DKQTCTLFFS 1600 WHTPLACEQE 1610 VECTVRNGSS 1620 IIDLSPLIHR 1630 TGGYEAFDES 1640 EDAASDTNPD 1650 FYINICQPLN 1660 PMHGVPCPAG 1670 AAVCKVPVDG 1680 APIDIGRVTG 1690 PPILNPIANE 1700 VYLNFESSTP 1710 CLADKHFNYT 1720 SLIAFHCKRG 1730 VSMGTPKLLR 1740 TSDCDFVFEW 1750 ETPLVCPDEV 1760 TTEGCSLTDE 1770 QLSYSFNLSS 1780 LSKSTFKVTR 1790 DSRTYSVGVC 1800 TAAAGLDQGG 1810 CKDGGVCLLS 1820 GSRGASFGRL 1830 ASMKLDYRHQ 1840 DEAVILSYAN 1850 GDNCPPETEE 1860 GDPCVFPFTL 1870 NGKSYEECVL 1880 EGRARLWCAT 1890 TADYDRDHEW 1900 GFCRHSNSHR 1910 TSAIIFKCDE 1920 DADVGRPQVF 1930 SEVRGCEVTF 1940 EWKTKVVCPP 1950 KKMECKFVQK 1960 HRTYDLRLLS 1970 SLTGSWFFVH 1980 DGASYYLNLC 1990 QRIYKGPLDC 2000 SDRASVCKKN 2010 PSGNVQVLGL 2020 VHTQKLDVIG 2030 DRVVVTYSKG 2040 HQCGGNKTAS 2050 TVIELTCAKT 2060 VGRPSFSRFD 2070 VDSCTYHVRW 2080 DSRAACAVKP 2090 QEVHMVNGTF 2100 TNPASGQSFS 2110 LGDIYFKRFS 2120 ASGDMRANGD 2130 KYLYEIQLSS 2140 ITSATHPACA 2150 GANICQVKPN 2160 DQHFSRKVGT 2170 SDKTKYYIQD 2180 GDLDVVFASS 2190 SKCGKDKTKS 2200 VSSTIFFHCD 2210 PLVKDGSPEF 2220 SHETADCQYL 2230 FSWYTSAVCP 2240 LEAGFGKNTG 2250 DDEPEHKGLS 2260 ERSQAVGAIL 2270 SLLLVALTGC 2280 LLTLLLYKKE 2290 RREAVMSRLT 2300 SCCRRGASVS 2310 YKYSKVNKEE 2320 EADENETEWL 2330 MEEIQLPTPR 2340 PGKEAQENGH 2350 ITTKSVKAEA 2360 LSSLRGDDQD 2370 SEDEVLTIPE 2380 VKVHPGRGPG 2390 DEGAHPMRPP 2400 QRQVLRERAD 2410 DRVGLVLEEP 2420 ARRGRPRAAH 2430 NKAVNSFHDD SDEDLLHI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0010008	endosome membrane
Cellular Component	GO:0000139	Golgi membrane
Molecular Function	GO:0005537	D-mannose binding
Molecular Function	GO:0038023	signaling receptor activity
Biological Process	GO:0007041	lysosomal transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.