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Overview

Uniprot IDA0A5G2R1Z5
Protein NameHeat shock 70 kDa protein 14
Gene NameHSPA14
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
397 LKIECSAKDILVKGV
68 SNTVMKVKQILGRSS

Function

Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity

Protein Sequence

10 MAAIGVHLGC 20 TSACVAVYKD 30 GRADVVANDA 40 GDRVTPAVVA 50 YTENEEVVGL 60 AAKQSRIRNI 70 SNTVMKVKQI 80 LGRSSDDPQA 90 QKYISESKCL 100 VIEKNGKLRY 110 EIDTGEEMKF 120 VNPEDVARLI 130 FSKMKETAHS 140 VLGPDANDVV 150 ITVPFDFGEK 160 QKNALGEAAR 170 AAGFNVLRLI 180 HEPSAALLAY 190 GIGQDSPTGK 200 SNILVFKLGG 210 TSLSISVMQV 220 NSGIYRVLST 230 NTDNNIGGTH 240 FTETLAQYLA 250 SEFQRSFKHD 260 VRGNARAMMK 270 LMNSADTAKH 280 SLSTLGSANC 290 FLDSLYEGQD 300 FDCNVSRARF 310 ELLCSPLFNK 320 CIEAIRGLLE 330 QSGFTADDIN 340 KVVLCGGSSR 350 IPRLQQMIKE 360 LFPAVELLNS 370 IPPDEVIPIG 380 AAIEAGILIG 390 KENLLVEDSL 400 KIECSAKDIL 410 VKGVDESGAN 420 SFRVLFPSGT 430 PLPARRQHML 440 QAPGSISSVC 450 LELYESDGKN 460 SAKEENKFAQ 470 VVLQDLDKKE 480 NGLRDILAVL 490 TMKRDGSLHV 500 TCTDQETGKC EAITIEVAS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0005840 ribosome
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0031072 heat shock protein binding
Molecular Function GO:0044183 protein folding chaperone
Biological Process GO:0042026 protein refolding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.