Search Results
Overview
| Uniprot ID | A0A5G2R267 |
|---|---|
| Protein Name | Methylthioribulose-1-phosphate dehydratase |
| Gene Name | APIP |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 146 | EMIKGIKKCTSGGYY |
Function
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death
Protein Sequence
10
MSGCHAPEGD
20
CSSRQCLAQD
30
KEHPRYLIPE
40
LCKQFYHLGW
50
VTGTGGGISL
60
KHGNEIYIAP
70
SGVQKERIQP
80
EDMFVCDIDE
90
QDISGPPPHK
100
NLKKSQCTPL
110
FMNAYTMRGA
120
GAVIHTHSKA
130
AVMATLLFPG
140
REFKITHQEM
150
IKGIKKCTSG
160
GYYRYDDMLV
170
VPIIENTPEE
180
DLKERMARAM
190
NEYPDSCAVL
200
VRRHGVYVWG
210
ETWEKAKTMC
220
ECYDYLFDVA
230
VSMKKVGLDP
240
TQLPVGENGI
V
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046570 | methylthioribulose 1-phosphate dehydratase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0019509 | L-methionine salvage from methylthioadenosine |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0051289 | protein homotetramerization |
| Biological Process | GO:0070269 | pyroptotic inflammatory response |
| Biological Process | GO:0070372 | regulation of ERK1 and ERK2 cascade |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.