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Overview

Uniprot IDA0A5G2R284
Protein NameLow-density lipoprotein receptor
Gene NameLDLR
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
285 CEGPNKFKCQSGECI

Function

Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization

Protein Sequence

10 HKGTLWIHTL 20 DSASNHDVKI 30 SHLEEKCGRN 40 EFQCRDGKCI 50 SYKWICDGNT 60 ECKDGSDESL 70 ETCMSVTCKI 80 GDFSCGGRVN 90 RCIPESWRCD 100 GQQDCENGSD 110 EEGCSPKTCS 120 QDEFRCQDGK 130 CIAPKFVCDS 140 DRDCLDGSDE 150 ASCPTPTCGP 160 ASFQCNSSTC 170 IPELWACDGD 180 PDCEDGSDEW 190 PQHCRSHSSS 200 LPERSNNPCS 210 ALEFHCHSGE 220 CIHSSWRCDG 230 DTDCKDKSDE 240 ENCDVATCRP 250 DEFQCSDGTC 260 IHGSRQCDRE 270 YDCKDLSDEQ 280 GCVNVTLCEG 290 PNKFKCQSGE 300 CISLDKVCNS 310 VRDCRDWSDE 320 PLKECGTNEC 330 LDNKGGCSHI 340 CNDLKIGYEC 350 LCPEGFQLVD 360 KHRCEDIDEC 370 QDPDACSQIC 380 VNLEGSYKCQ 390 CEEGFQLEPL 400 TKACKAIGTI 410 AYLFFTNRHE 420 VRKMTLDRSE 430 YTSLIPNLKN 440 VVALDTEVAS 450 NRIYWSDLSQ 460 RKIYSTQINR 470 APSFSSYDTI 480 IGEDLQAPDG 490 LAVDWIHSNI 500 YWTDSILGTV 510 SVADTKGVKR 520 KTLFQEKGSK 530 PRAIVVDPVH 540 GFMYWTDWGT 550 PAKIKKGGLN 560 GVDVYSLVTE 570 DIQWPNGITL 580 DLSGGRLYWV 590 DSKLHSISSI 600 DVNGGNRKTV 610 LEDKTKLAHP 620 FSLAIFEDKV 630 FWTDVINEAI 640 FSANRLTGSD 650 IHLMAENLLS 660 PEDIVLFHNL 670 TQPRGVNWCE 680 RTALQNGGCQ 690 YLCLPAPQIN 700 PRSPKFTCAC 710 PDGMLLAKDM 720 RSCLTETEPA 730 GTTQGPSMVN 740 STAVGPKHTA 750 SSELTTAESV 760 TMSQHALGDV 770 AGRGVTEKPQ 780 SVGALYIVLP 790 IALLILLFFG 800 TFLLWKNWRL 810 KSINSINFDN 820 PVYQKTTEDE 830 VHICRSQDGY 840 TYPSRQMVSL EDDVA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0005769 early endosome
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005770 late endosome
Cellular Component GO:0034362 low-density lipoprotein particle
Cellular Component GO:0005764 lysosome
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005509 calcium ion binding
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0006897 endocytosis
Biological Process GO:0006869 lipid transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.