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Overview

Uniprot ID	A0A5G2R2F3
Protein Name	Sec1 family domain-containing protein 1
Gene Name	SCFD1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
280	RPKRKNKKSYDLTPV
396	YEEKIMSKTTLDKSL

Function

Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi

Protein Sequence

10 MVGVKMAAAA 20 AASIRERQTV 30 ALKRMLNFNV 40 PHVKNSAGEP 50 VWKVLIYDRF 60 GQDIISPLLS 70 VKELRDMGIT 80 LHLLLHSDRD 90 PIPDVPAVYF 100 VMPTEENIDR 110 LCQDLRNQLY 120 ESYYLNFISA 130 ISRSKLEDIA 140 NAALAASAVT 150 QVAKVFDQYL 160 NFITLEDDMF 170 VLCNQNKEIV 180 SYRAINRTDI 190 TDTEMETVKL 200 DKKLRENLRD 210 ARNSLFTGDT 220 LGAGQFSFQR 230 PLLVLVDRNI 240 DLATPLHHTW 250 TYQALVHDVL 260 DFHLNRVNLE 270 ESSGTETSPA 280 GARPKRKNKK 290 SYDLTPVDKF 300 WQKHKGSPFP 310 EVAESVQQEL 320 ESYRAQEDEV 330 KRLKSIMGLE 340 GEDEGAISML 350 SDNTAKLTSA 360 VSSLPELLEK 370 KRLIDLHTNV 380 ATAVLEHIKA 390 RKLDVYFEYE 400 EKIMSKTTLD 410 KSLLDIISDP 420 DAGTPEDKMR 430 LFLIYYISAQ 440 QAPSEADLEQ 450 YKKALTDAGC 460 NLNPLQYIKQ 470 WKAFAKMASA 480 PASYGNTTTK 490 PMGLLSRVMN 500 TGSQFVMEGV 510 KNLVLKQQNL 520 PVTRILDNLM 530 EMKSNPETDD 540 YRYFDPKMLR 550 GNDSSVPRNK 560 NPFQEAIVFV 570 VGGGNYIEYQ 580 NLVDYIKGKQ 590 GKHILYGCSE 600 LFNATQFIKQ LSQLGQK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0032580	Golgi cisterna membrane
Biological Process	GO:0015031	protein transport
Biological Process	GO:0016192	vesicle-mediated transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.