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Overview

Uniprot IDA0A5G2R2F7
Protein Name116 kDa U5 small nuclear ribonucleoprotein component
Gene NameEFTUD2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
147 QERGVGIKSTPVTVV
209 LNTERLIKHAVQERL
665 QITWNRKKLGEFFQT

Function

Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs

Protein Sequence

10 MDDEDDDDDV 20 GDHDEEHPGM 30 EVVLHEDKKY 40 YPTAEEVYGP 50 EVETIVQEED 60 TQPLTEPIIK 70 PVKTKKFTLM 80 EQTLPVTVYE 90 MDFLADLMDN 100 SELIRNVTLC 110 GHLHHGKTCF 120 VDCLIEQTHP 130 EIRKRYDQDL 140 CYTDILFTEQ 150 ERGVGIKSTP 160 VTVVLPDTKG 170 KSYLFNIMDT 180 PGHVNFSDEV 190 TAGLRISDGV 200 VLFIDAAEGV 210 MLNTERLIKH 220 AVQERLAVTV 230 CINKIDRLIL 240 ELKLPPTDAY 250 YKLRHIVDEV 260 NGLISMYSTD 270 ENLILSPLLG 280 NVCFSSSQYS 290 ICFTLGSFAK 300 IYADTFEFRK 310 HPWGWRKFTK 320 KAPTSSSQRS 330 FVEFILEPLY 340 KILAQVVGDV 350 DTSLPRTLDE 360 LGIHLTKEEL 370 KLNIRPLLRL 380 VCKKFFGEFT 390 GFVDMCVQHI 400 PSPKVGAKPK 410 IEHTYTGGVD 420 SDLGEAMSDC 430 DPDGPLMCHT 440 TKMYSTDDGV 450 QFHAFGRVLS 460 GTIHAGQPVK 470 VLGENYTLED 480 EEDSQICTVG 490 RLWISVARYH 500 IEVNRVPAGN 510 WVLIEGVDQP 520 IVKTATITEP 530 RGNEEAQIFR 540 PLKFNTTSVI 550 KIAVEPVNPS 560 ELPKMLDGLR 570 KVNKSYPSLT 580 TKVEESGEHV 590 ILGTGELYLD 600 CVMHDLRKMY 610 SEIDIKVADP 620 VVTFCETVVE 630 TSSLKCFAET 640 PNKKNKITMI 650 AEPLEKGLAE 660 DIENEVVQIT 670 WNRKKLGEFF 680 QTKYDWDLLA 690 ARSIWAFGPD 700 ATGPNILVDD 710 TLPSEVDKAL 720 LGSVKDSIVQ 730 GFQWGTREGP 740 LCDELIRNVK 750 FKILDAVVAQ 760 EPLHRGGGQI 770 IPTARRVVYS 780 AFLMATPRLM 790 EPYYFVEVQA 800 PADCVSAVYT 810 VLARRRGHVT 820 QDAPIPGSPL 830 YTIKAFIPAI 840 DSFGFETDLR 850 THTQGQAFSL 860 SVFHHWQIVP 870 GDPLDKSIVI 880 RPLEPQPAPH 890 LAREFMIKTR 900 RRKGLSEDVS 910 ISKFFDDPML 920 LELAKQDVVL NYPM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005681 spliceosomal complex
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Biological Process GO:0006397 mRNA processing
Biological Process GO:0008380 RNA splicing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.