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Overview

Uniprot IDA0A5G2R2I8
Protein NameReceptor protein-tyrosine kinase
Gene NameEGFR
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
212 ENCQKLTKVICAQQC

Function

No function data available.

Protein Sequence

10 MRRSWAGGAA 20 LLALLAAHFQ 30 ASPALEEKKV 40 CQGTSNKLTQ 50 LGTFEDHFLS 60 LQRMFNNCEV 70 VLGNLEITYM 80 QNSYNLSFLK 90 TIQEVAGYVL 100 IALNTVEKIP 110 LENLQIIRGN 120 VLYENTHALA 130 VLSNYGANKT 140 GLRELPMRNL 150 QEILQGAVRF 160 SNNPALCHAE 170 SIQWRDIVNS 180 DFLSNMSMDF 190 QSQLGSCPKC 200 DPGCLNGSCW 210 GAGKENCQKL 220 TKVICAQQCS 230 GRCRGRSPSD 240 CCHNQCAAGC 250 TGPRESDCLV 260 CRRFRDEATC 270 KDTCPPLMLY 280 NPTTYQMDVN 290 PLGKYSFGAT 300 CVKKCPRNYV 310 VTDHGSCVRA 320 CSSDSYEVEE 330 DGVRKCKKCD 340 GPCGKVCNGI 350 GIGEFKDTLS 360 INATNIKHFR 370 NCTSISGDLH 380 ILPVAFRGDS 390 FTRTPPLDPK 400 ELDILKTVKE 410 ITGFLLIQAW 420 PENRTGLHAF 430 ENLEIIRGRT 440 KQHGQFSLAV 450 VGLDIASLGL 460 RSLKEISDGD 470 VIVSGNRNLC 480 YANTISWKKL 490 FGTASQKTKI 500 INNRSEKECK 510 AMGHICNPLC 520 SSEGCWGPEP 530 RDCMSCRNFS 540 RGKECVEKCN 550 VLEGEPREFV 560 ENAECVQCHP 570 ECLPQAKNVT 580 CMGRGPDSCV 590 RCAHYIDGPH 600 CVKTCPAGIA 610 GENSTLIWKF 620 ADANHVCHLC 630 HPNCTYGCVG 640 PGLEGCAVDR 650 PKIPSIATGI 660 VGGLLLAVVL 670 ALGVGLFLRR 680 RHIVRKRTLR 690 RLLQERELVE 700 PLTPSGEAPN 710 QALLRILKET 720 EFKKVKVLGS 730 GAFGTVYKGL 740 WIPEGEKVKI 750 PVAIKELREA 760 TSPKANKEIL 770 DEAYVMASVD 780 NPHVCRLLGI 790 CLTSTVQLIT 800 QLMPFGCLLD 810 YVREHKDNIG 820 SQHLLNWCVQ 830 IAKGMNYLED 840 RRLVHRDLAA 850 RNVLVKTPQH 860 VKITDFGLAK 870 LLGAEEKEYH 880 AEGGKVPIKW 890 LALESILHRV 900 YTHQSDVWSY 910 GVTVWELMTF 920 GSKPYDGIPA 930 SEISTVLEKG 940 ERLPQPPICT 950 IDVYMIMVKC 960 WMIDADSRPK 970 FRELIIEFSK 980 MARDPQRYLV 990 IQGDERMHLP 1000 SPTDSNFYRA 1010 LMDEEDMEDV 1020 VDADEYLVPQ 1030 QGFFHSPATS 1040 RTPLLSSLSA 1050 TSSTPAVACV 1060 DRNGQQSYPL 1070 KEDSFLQRYS 1080 SDPTGALTED 1090 SLDDTFLPAP 1100 EYVNQSVPKR 1110 PAGSVQNPVY 1120 HNQPLSAAPG 1130 RDPHYQNSHS 1140 NAVGNPEYLN 1150 TPRPACINGG 1160 LDGPAFWAQT 1170 GSHQINLDNP 1180 DYQQAFFPKE 1190 AKSNGICKGP 1200 AAENAEYLRA 1210 APASSDLTGA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009925 basal plasma membrane
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0009986 cell surface
Cellular Component GO:0030139 endocytic vesicle
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0043235 receptor complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0048408 epidermal growth factor binding
Molecular Function GO:0005006 epidermal growth factor receptor activity
Molecular Function GO:0004714 transmembrane receptor protein tyrosine kinase activity
Biological Process GO:0007173 epidermal growth factor receptor signaling pathway
Biological Process GO:0038134 ERBB2-EGFR signaling pathway
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0030182 neuron differentiation
Biological Process GO:0050679 positive regulation of epithelial cell proliferation
Biological Process GO:0043410 positive regulation of MAPK cascade

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.