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Overview

Uniprot ID	A0A5G2R2Q4
Protein Name	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
Gene Name	PAICS
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
109	IATGSFLKRNPGVKE
79	IKTAFTRKCGETAFI

Function

Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway

Protein Sequence

10 FISTVLNIGK 20 KLYEGKTKEV 30 YELLDSPGKV 40 LLQSKDQITA 50 GNAARKNHLE 60 GKAAISNTIT 70 SCVFQLLQEA 80 GIKTAFTRKC 90 GETAFIAPKC 100 EMIPIEWVCR 110 RIATGSFLKR 120 NPGVKEGYKF 130 YPPKVEMFFK 140 DDANNDPQWS 150 EEQLIAANFC 160 FAGLVIGQTE 170 VDVMSHATQA 180 IFEILEKSWL 190 PQNCTLVDMK 200 VQIQWRFEKI 210 VLADVIDNDS 220 WRLWPSGDRS 230 QQKDKQSYRD 240 LKEVTPEGLQ 250 MVKKNFEWVA 260 ERVELLLKTE 270 SQCRVVVLMG 280 STSDLSHCEK 290 IKKACGNFGI 300 PCELRVTSAH 310 KGPDETLRIK 320 AEYEGDGIPT 330 VFVAVAGRSN 340 GLGPVMSGNT 350 AFPVISCPPL 360 SPDWGAQDVW 370 SSLRLPSGLG 380 CSTILSPEGS 390 AQFAAQIFGL 400 NNHLVWAKLR 410 ANVLNTWISL 420 KQADKKIREG NL

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004638	phosphoribosylaminoimidazole carboxylase activity
Molecular Function	GO:0004639	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Biological Process	GO:0006189	'de novo' IMP biosynthetic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.