Overview
| Uniprot ID | A0A5G2R2Y3 |
|---|
| Protein Name | Elongin-B |
|---|
| Gene Name | ELOB |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 11 |
FLMIRRHKTTIFTDA |
| 28 |
SSTVFELKRIVEGIL |
| 36 |
RIVEGILKRPPDEQR |
| 46 |
PDEQRLYKDDQLLDD |
| 55 |
DQLLDDGKTLGECGF |
Function
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells
Protein Sequence
10
MDVFLMIRRH
20
KTTIFTDAKE
30
SSTVFELKRI
40
VEGILKRPPD
50
EQRLYKDDQL
60
LDDGKTLGEC
70
GFTSQTARPQ
80
APATVGLAFR
90
AARPILRWCV
100
LPRGQWGEHA
110
RCVKHLMAVP
120
WRPPRSLVRA
130
PAYTGGGLPE
140
GPAPLVLSWP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031462 |
Cul2-RING ubiquitin ligase complex |
| Cellular Component |
GO:0031466 |
Cul5-RING ubiquitin ligase complex |
| Cellular Component |
GO:0070449 |
elongin complex |
| Cellular Component |
GO:0030891 |
VCB complex |
| Molecular Function |
GO:0001222 |
transcription corepressor binding |
| Molecular Function |
GO:0031625 |
ubiquitin protein ligase binding |
| Biological Process |
GO:0140958 |
target-directed miRNA degradation |
| Biological Process |
GO:0006368 |
transcription elongation by RNA polymerase II |
| Biological Process |
GO:0006367 |
transcription initiation at RNA polymerase II promoter |
| Biological Process |
GO:0140627 |
ubiquitin-dependent protein catabolic process via the C-end degron rule pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.