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Overview

Uniprot IDA0A5G2R3E4
Protein Name-
Gene NameACADVL
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
221 GILLFGTKAQKEKYL
324 VTHGPPEKKMGIKAS
398 NRTQFGEKIHNFGVI
408 NFGVIQEKLARMAML
582 VKLIKHKKDIVNEQF
665 RNFKSISKALIERGG

Function

Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on fatty acyl-CoAs with saturated 12 to 24 carbons long primary chains

Protein Sequence

10 MGAVRAAVGL 20 GWLPPPTANR 30 GLPLGPSHLP 40 TGCPGAESRG 50 KGRQGALGWK 60 LGERLRPPLT 70 ASSNPLLSLA 80 LRNPKTKPDA 90 LSSEASTREK 100 RIQTESKSFA 110 VGMFKGQLTT 120 DQVFPYPSVL 130 NEDQTQVLQE 140 LVGPVSRFFE 150 EVNDPAKNDM 160 LERVEETTMQ 170 GLKELGAFGL 180 QVPSELGGVG 190 LCNTQYARLV 200 EIVGMHDLGV 210 GIVLGAHQSI 220 GFKGILLFGT 230 KAQKEKYLPK 240 VASGEVMAAF 250 CLTEPSSGSD 260 AASIRSSAVP 270 SPCGKYYTLN 280 GSKIWISNGG 290 LADLFTVFAK 300 TPVTDPATGA 310 VKEKITAFLV 320 ERGFGGVTHG 330 PPEKKMGIKA 340 SNTAEVYFDE 350 VQVPTENVLG 360 EVGGGFKVAM 370 HILNNGRFGM 380 AAAMAGTMKA 390 IIAKAVNHAA 400 NRTQFGEKIH 410 NFGVIQEKLA 420 RMAMLQYVTE 430 SMAYMVSANM 440 DQGSTDFQIE 450 AAISKIFGSE 460 AAWKVTDECI 470 QVMGGMGFMK 480 EPGVERVLRD 490 LRIFRIFEGT 500 NDILRLFVAL 510 QGCMDKGKEL 520 SGLGNALKNP 530 FGNAGLLLGE 540 ASKQLRRRAG 550 LGSGLSLSGI 560 IHPELSRSGQ 570 LAVQALEQFA 580 TVVEVKLIKH 590 KKDIVNEQFV 600 LQRLADSAID 610 LYAMVVVLSR 620 ASRSLSEGQS 630 TAQHEKMLCD 640 SWCIEAAARI 650 RENMAALQSD 660 PQQQELFRNF 670 KSISKALIER 680 GGVVTSNPLG V

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0042645 mitochondrial nucleoid
Molecular Function GO:0050660 flavin adenine dinucleotide binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0004466 long-chain fatty acyl-CoA dehydrogenase activity
Molecular Function GO:0017099 very-long-chain fatty acyl-CoA dehydrogenase activity
Biological Process GO:0030855 epithelial cell differentiation
Biological Process GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
Biological Process GO:0045717 negative regulation of fatty acid biosynthetic process
Biological Process GO:0046322 negative regulation of fatty acid oxidation
Biological Process GO:0090181 regulation of cholesterol metabolic process
Biological Process GO:0001659 temperature homeostasis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.