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Overview

Uniprot IDA0A5G2R3I6
Protein NameAcetyltransferase component of pyruvate dehydrogenase complex
Gene NameDLAT
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
372 PATPAGPKGRLFVSP
382 LFVSPLAKKLASEKG
396 GIDLTQIKGTGPDGR
407 PDGRIIKKDIDSFVP
493 KMLEGRSKISVNDFI

Function

The pyruvate dehydrogenase (PDH) complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3);. Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acetyl groups from acetyl-lipoyl moiety generated by the pyruvate dehydrogenase, leading to acetyl-CoA formation

Protein Sequence

10 MWRVCARRAQ 20 NAAPRAGFGA 30 RWTALREEPG 40 APCAAPRAGS 50 VPARCSSTTR 60 GYGRSRALCG 70 WSASSWATPQ 80 NRILLQLWGS 90 PNRRWYSLPP 100 HQKVPLPSLS 110 PTMQAGTIAR 120 WEKKEGDKIN 130 EGELIAEVET 140 DKATVGFESL 150 EECYMAKILV 160 AEGTRDVPVG 170 AIICITVEKP 180 EDIEAFKNYT 190 LDSSAAPAPQ 200 AAPAPTPAAA 210 APAPTPSAQA 220 PGSSYPTHMQ 230 EQPQLQQWQC 240 QILNHCITRE 250 VVLPALSPTM 260 TMGTVQRWEK 270 KVGEKLSEGD 280 LLAEIETDKA 290 TIGFEVQEEG 300 YLAKILIPEG 310 TRDVPLGTPL 320 CIIVEKEADI 330 PAFADYRPTE 340 VTDLKPPAPP 350 PTPSPVTPVP 360 PAPQPVAPTP 370 AATRPATPAG 380 PKGRLFVSPL 390 AKKLASEKGI 400 DLTQIKGTGP 410 DGRIIKKDID 420 SFVPTKAAPP 430 PAAAVPPPSP 440 GVAPVPTGVF 450 TDIPISNIRR 460 VIAQRLMQSK 470 QTIPHYYLSV 480 DVNMGEVLLV 490 RKELNKMLEG 500 RSKISVNDFI 510 IKASALACLK 520 VPEANSSWLD 530 TVIRQNHVVD 540 ISVAVSTPAG 550 LITPIVFNAH 560 IKGLETIAND 570 VVSLATKARE 580 GKLQPHEFQG 590 GTFTISNLGM 600 FGIKNFSAII 610 NPPQACILAV 620 GASEDRLFPA 630 DNEKGFDVAS 640 MMSVTLSCDH 650 RVVDGAVGAQ 660 WLAEFRKYLE KPITMLL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0045254 pyruvate dehydrogenase complex
Molecular Function GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity
Molecular Function GO:0042802 identical protein binding
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0042867 pyruvate catabolic process
Biological Process GO:0006086 pyruvate decarboxylation to acetyl-CoA

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.