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Overview

Uniprot ID	A0A5G2R3T2
Protein Name	Condensin-2 complex subunit D3
Gene Name	NCAPD3
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1187	KLISQVQKKNLIENI
1416	TPFPVKGKSLPNRPT

Function

Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size

Protein Sequence

10 MAARQGLESS 20 LQPWNTLDLS 30 PEWVDAVWEV 40 EFTETEPLDP 50 GIEAEIEESG 60 LRAFTDLYDS 70 LFSFATEEHG 80 ATESIWTFFA 90 ENNISHKALM 100 AVFYHFVQKV 110 HKKNVNVKQR 120 KFGLHAAALY 130 FLLLEVPGSV 140 ANQVFHPVMF 150 DKCVQILKKS 160 WPQESSLSQK 170 RKKEQPKNSQ 180 ANPRGNKKRG 190 RPLRKESLEM 200 DEIIEEQEDE 210 ESIFFSAWDL 220 CQIRNAIFDL 230 LKNFLRLLPR 240 FSLKEKPQCV 250 QNCIEVFVAL 260 TNLEPVPREF 270 HVTQARNPNQ 280 AKYIPELAYH 290 GLYLMCSPFH 300 GEGDKVIRCV 310 FHQMLYLILM 320 LEVGEGSHHA 330 PLTITPTVIN 340 GRNLAVQFIS 350 SLVDELKEGI 360 FPVLRILLQH 370 ICVKVVDKSE 380 YRTYAAQSLV 390 QLLNKLPCAE 400 YASFIAWFYG 410 CSRNPKTSRR 420 VFTLDVALAL 430 LELPEREVEG 440 TLPPEHQKFL 450 KHKFLVQEIL 460 FARCVDKAPA 470 VRSKALSSFA 480 HCLEFSSTAT 490 SESVLGLLID 500 SEYGEHGETE 510 LDPCWSRTFS 520 YQKKTLNPSG 530 SSEVINIDNS 540 GETAGSSEMC 550 LMTMLKSRMG 560 DEKANVRKSA 570 LQVLVSVLKH 580 CDVSGLKEEL 590 SILQDHCRDI 600 ALSVRKQALQ 610 SLTELLVAQP 620 RCVQIQKAWL 630 WGVIPAVMDS 640 ERTVQDKALE 650 CLDQLLLQNI 660 QHHSQFHHED 670 DSQVLTWALL 680 SLLSTESQEL 690 GRYLNKAFQG 700 WSKKEKFSST 710 FVNNVLSHTG 720 KEHCAPAWML 730 LSKVVCSAPT 740 LDHTKIMKSW 750 EQMSRQPNPN 760 ADTLGHILCV 770 IGHIAKHLPK 780 STRDKVTNVV 790 EQKLSGFQWS 800 PKLIKPAVDT 810 LQHLCRASAE 820 TPVEEQKLLA 830 QVCGDILSTC 840 VHCLSDVLLK 850 EDGTRRMNED 860 LVVKYIFTLG 870 DVAQLCPARV 880 DKRAFLLIQS 890 ILAASPSTDH 900 LPASDPGGSE 910 ATASQPLPGI 920 HSSIMPSVIR 930 AHAVIALGKL 940 CLQHEDLAKR 950 SIPALVRELE 960 VCSDMAVRNN 970 VVITMCDLCK 980 RYTAMVDKYI 990 PNISACLKDS 1000 EPFIRRQTLL 1010 LLTDLLQEDF 1020 VKWKGPLFFR 1030 FVSTLVDPDL 1040 AIASTGKFCL 1050 AQLLLKRNPA 1060 MFFQHFNECI 1070 FHFNSYEKHE 1080 KYNRFPQSER 1090 EKRLFSLKGK 1100 TNKEKRMKIY 1110 SFLLEHFTDE 1120 QRFNITSKIC 1130 LSTLEGPSVL 1140 ASELLSDTFE 1150 VLSSKEIKLL 1160 AMRNKVDKDL 1170 PVEEEDLALA 1180 NVVLQEAQKK 1190 LISQVQKKNL 1200 IENIIPVIIS 1210 LKTVLEKNKI 1220 PALRDLMHYL 1230 REVMQDYRAE 1240 IEEFFASDTQ 1250 LASELEYDMK 1260 QYQEQEQMEQ 1270 ELISSSEKIP 1280 APTSLESTMA 1290 NVASQPSTSR 1300 PRTAHAPAPL 1310 SLDTRPLKRL 1320 MPKASHRSMS 1330 PSTIAILNSV 1340 KKAVESNSQH 1350 RSRSLGLPPF 1360 TVCPKSLGEP 1370 SEGASSQDLE 1380 RESSGAIDLL 1390 TKRGISTPER 1400 TIQNVTFGTG 1410 LSCVGSPQTP 1420 FPVKGKSLPN 1430 RPTSRVCELG 1440 SLGACETLSE 1450 DMEAQGQRDV 1460 LCLSLPDMTP 1470 PQPAQWNVTS 1480 PARGRDSAAP 1490 RRSRRKAPLK TAN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000779	condensed chromosome, centromeric region
Cellular Component	GO:0000796	condensin complex
Cellular Component	GO:0031981	nuclear lumen
Biological Process	GO:0051301	cell division
Biological Process	GO:0007076	mitotic chromosome condensation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.