Search Results
Overview
| Uniprot ID | A0A5G2R4K6 |
|---|---|
| Protein Name | DnaJ homolog subfamily C member 7 |
| Gene Name | DNAJC7 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 257 | NNIKTNAKLYCNRGT |
| 271 | TVNSKLRKLDDAIED |
Function
Acts as a co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm
Protein Sequence
10
MAAAAECDVV
20
MAATGPELLD
30
DEEAKREAES
40
FKEQGNAYYA
50
KKDYNEAYNY
60
YTKAIDMCPK
70
NASYYGNRAA
80
TLMMLGRFRE
90
ALGDAQQSVR
100
LDDSFVRFKN
110
ANAVIEYEKI
120
AETDFEKRDF
130
RKVVFCMDRA
140
LEFAPACHRF
150
KILKAECLAM
160
LGRYPEAQSV
170
ASDILRMDST
180
NADALYVRGL
190
CLYYEDCIEK
200
AVQFFVQALR
210
MAPDHEKACI
220
ACRNAKALKA
230
KKEDGNKAFK
240
EGNYKLAYEL
250
YTEALGIDPN
260
NIKTNAKLYC
270
NRGTVNSKLR
280
KLDDAIEDCT
290
HAVKLDDTYI
300
KAYLRRAQCY
310
MDTEQYEEAV
320
RDYEKVYQTE
330
KTKEHKQLLK
340
NAQLELKKSK
350
RKDYYKILGV
360
DKNASEDEIK
370
KAYRKRALMH
380
HPDRHSGASA
390
EVQKEEEKKF
400
KEVGEAFTIL
410
SDPKKKTRYD
420
SGQDLDEEGM
430
NMGDFDANNI
440
FKAFFGGPGG
450
FSFEASGPGN
FFFQFG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005634 | nucleus |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.