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Overview

Uniprot IDA0A5G2R4M3
Protein NameInter-alpha-trypsin inhibitor heavy chain H3
Gene NameITIH3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
197 KKGHVSFKPSLDQQR
99 DKTAGLVKASGRKLE

Function

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes

Protein Sequence

10 MGKTVLRVVV 20 NGIEVYSTKV 30 SCKVTSRFAH 40 NVVTTRAVNH 50 ADTAKEVSFD 60 VELPKTAFIT 70 NFTLTIDGVT 80 YPGNVKEKEV 90 AKKQYEKAVS 100 QDKTAGLVKA 110 SGRKLEKFTV 120 SVNVAAGSKV 130 TFELTYEELL 140 KRHKGKYEMY 150 LKVQPKQLVK 160 HFEITADIFE 170 PQGISTLDAE 180 ASFITNDLLG 190 SALTKSFSGK 200 KGHVSFKPSL 210 DQQRSCPTCT 220 DSLLKGDFII 230 TYDVNRESPA 240 NVQIVNGYFV 250 HFFAPQGLPV 260 VPKNVVFVID 270 VSGSMYGRKM 280 EQTKDALLKI 290 LDDIKEDDYL 300 NFVLFSGDVT 310 TWKDSLVQAT 320 PENIQKAREF 330 VRNIRDQGMT 340 NINDGLLTGI 350 SMLNKAREEH 360 KVPERSTSII 370 IMLTDGDANM 380 GVSKPEKIQE 390 NVRNAIGGKF 400 PLYNLGFGNN 410 LNYNFLESMA 420 LENHGLARRI 430 YEDSDANLQL 440 QGFYEEVANP 450 LLTSVEVGYP 460 ENAIQDLTQN 470 TYQHFYDGSE 480 IVVAGRLADE 490 DMNSFRADVK 500 GHGAINDLTF 510 TEEVDMKEME 520 EALKERDYIF 530 GNYIERLWAY 540 LTIEQLLEKR 550 KNAQGKEKET 560 LTAQALDLSL 570 KYHFVTPLTS 580 MVVTKPEDNE 590 NQTAIADKPG 600 EEPVDAVTPS 610 TAYLTSYQPP 620 VTPYYYVDGD 630 PHFIIQVPEK 640 DDAICFNIDE 650 DPGTVLRLIQ 660 DPVTGLTVNG 670 QIIGEKRSSQ 680 DSQPRKTYFG 690 KLGIANAHLD 700 FRIEVTPERI 710 TLWNGAAQST 720 FSWLDTVMVT 730 QDGLSVMINK 740 KNMVVSFGDG 750 ATFVVVLHQV 760 WKKQPNHHDF 770 LGFYVVDSHR 780 MSTQTHGLLG 790 QFFHPFDFKV 800 SDIHPGSDPT 810 KPDATMVVKN 820 HRLTVTRGSQ 830 KDYRKDASIG 840 VKVACWFVHD 850 NGQGLIDGIH SDYIVPDLF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005576 extracellular region
Molecular Function GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process GO:0006953 acute-phase response
Biological Process GO:0030212 hyaluronan metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.