Search Results

Overview

Uniprot IDA0A5G2R4P6
Protein NameCyclin-G-associated kinase
Gene NameGAK
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
91 GQLVEFLKKVESKGP

Function

Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly

Protein Sequence

10 MISAHRDSFT 20 SSFPDLGSGR 30 EYALKRLLSN 40 EEEKNRVIIQ 50 EVCFMKKLSG 60 HPNIVQFCSA 70 ASIGKEESDT 80 GQAEFLLLTE 90 LCKGQLVEFL 100 KKVESKGPLS 110 CDTVLKIFYQ 120 TCRAVQHMHK 130 QKPPIIHRDL 140 KVENLLLSNQ 150 GTIKLCDFGS 160 ATTISHYPDY 170 SWSAQQRALV 180 EEEITRNTTP 190 MYRTPEIVDL 200 YSNFPIGEKQ 210 DIWALGCILY 220 LLCFRQHPFE 230 DGAKLRIVNG 240 KYVIPPDDTR 250 YSVFHGLIRA 260 TLKVNPEERL 270 SITELVNQLQ 280 EIAAARNVNP 290 KSPITELLEQ 300 NGGCGSAAPP 310 TGSASSGCSG 320 GLAVAEYDQP 330 YGGLLDILRG 340 GTERLFTNIK 350 DTSSKVIQSV 360 ASYAKGDLDI 370 SYITSRIAVM 380 SFPAEGVESA 390 IKNNVEDVRL 400 FLDSKHPGRY 410 TVYNLSPRTY 420 RPSRFHSRVS 430 ECGWVARRAP 440 SLHSLYSLCR 450 SMHAWLRQDP 460 KNVCVVHCMD 470 GRAASAVAVC 480 SFLCFCRLFS 490 TAEAAVYMFS 500 MKRCPPGIWP 510 SHKRYIEYVC 520 DMVAEEPITP 530 HSKPVLVKAV 540 AMTPVPLFSK 550 QRHGCRPFCE 560 VYVGDERVAT 570 TSQEYDKMRD 580 FRVEDGKAVI 590 PLDVAVQGDV 600 LVVIYHARST 610 LGGRLQAKMA 620 SMKMFQIQFH 630 TGFVPRNATT 640 VKFAKYDLDA 650 CDIQEKFPDL 660 FQVHLEVEVE 670 PRDRPSREAP 680 PWESASMRGL 690 NPKILFSSRE 700 EQQDVLSKFG 710 KPELPRQPGS 720 TAQYEAEGPG 730 PDLPHSSADA 740 NHFLHTLDWQ 750 EDRDTTAGPE 760 GHPAKEDPPA 770 AAEDGRESEP 780 SDEEATTLSA 790 ESGDTADEDA 800 PGPAAPPEDS 810 VDLLGLHAEA 820 GPAPCPQARG 830 GPPSNADLLS 840 CLLGAPPPAP 850 AGTTGRLLEG 860 DTSLLFSSPA 870 PPPSAPTAPR 880 EASAPAADPF 890 DPLLLPSDPV 900 SQPCSRPDLF 910 GEFLTSDSPA 920 GPPASFPSTH 930 SAPPPACSSD 940 FLRLGDLPTE 950 PSRVTASTSH 960 PDLLGGWDAW 970 AEASAPTSAT 980 EGPFFSPGGQ 990 PAPPGPPASQ 1000 PQSQNQDPFA 1010 DLGDLSSSLQ 1020 GSPAAPPPGG 1030 FGPKTGALPK 1040 ASGSWQTSRP 1050 SAQGTSWHPQ 1060 ARPPPKATAQ 1070 PRPNYTPGFS 1080 VIGSREERGV 1090 RAPGFGPRPR 1100 VSENDFEDLL 1110 SSQGFSSRAD 1120 RRGPRTVAEM 1130 RRQDQARDTD 1140 PLKLKLQDWT 1150 EGKERNIRAL 1160 LSTLHTVLWD 1170 GESRWTPVGM 1180 ADLVTPGQVK 1190 KQYRRAVLVV 1200 HPDKAQGQPY 1210 EQHARLIFME 1220 LSDAWAEFES QGCRPLF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030136 clathrin-coated vesicle
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004674 protein serine/threonine kinase activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.