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Overview

Uniprot IDA0A5G2R4Q7
Protein NameVacuolar protein sorting-associated protein 35
Gene NameVPS35
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
38 KRCLDKNKLMDALKH
419 ILTVLKLKHFHPLFE
552 ENSKVDDKWEKKCQK
659 QCALAASKLLKKPDQ

Function

Plays a role in vesicular protein sorting

Protein Sequence

10 MPTTQQSPQD 20 EQEKLLDEAI 30 QAVKVQSFQM 40 KRCLDKNKLM 50 DALKHASNML 60 GELRTSMLSP 70 KSYYELYMAI 80 SDELHYLEVY 90 LTDEFAKGRK 100 VADLYELVQY 110 AGNIIPRLYL 120 LITVGVVYVK 130 SFPQSRKDIL 140 KDLVEMCRGV 150 QHPLRGLFLR 160 NYLLQCTRNI 170 LPDEGEPTDE 180 ETTGDISDSM 190 DFVLLNFAEM 200 NKLWVRMQHQ 210 GHSRDREKRE 220 RERQELRILV 230 GTNLVRLSQL 240 EGVNVERYKQ 250 IVLTGILEQV 260 VNCRDALAQE 270 YLMECIIQVF 280 PDEFHLQTLN 290 PFLRACAELH 300 QNVNVKNIII 310 ALIDRLALFA 320 HREDGPGIPA 330 DIKLFDIFSQ 340 QVATVIQSRQ 350 DMPSEDVVSL 360 QVSLINLAMK 370 CYPDRVDYVD 380 KVLETTVEIF 390 NKLNLEHIAT 400 SSAVSKELTR 410 LLKIPIDTYN 420 NILTVLKLKH 430 FHPLFEYFDY 440 ESRKSMSCYV 450 LSNVLDYNTE 460 IVSQDQVDSI 470 MNLVSTLIQD 480 QPDQPAEDPD 490 PEDFADEQSL 500 VGRFIHLLRS 510 EDPDQQYLIL 520 NTARKHFGAG 530 GNQRIRFTLP 540 PLVFAAYQLA 550 FRYKENSKVD 560 DKWEKKCQKI 570 FSFAHQTISA 580 LIKAELAELP 590 LRLFLQGALA 600 AGEIGFENHE 610 TVAYEFMSQA 620 FSLYEDEISD 630 SKAQLAAITL 640 IIGTFERMKC 650 FSEENHEPLR 660 TQCALAASKL 670 LKKPDQGRAV 680 STCAHLFWSG 690 RNTDKNGEEL 700 HGGKRVMECL 710 KKALKIANQC 720 MDPSLQVQLF 730 IEILNRYIYF 740 YEKENDAVTI 750 QVLNQLIQKI 760 REDLPNLESS 770 FFFYLFVFVF 780 ILAFGGCTRG IWKFPG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005769 early endosome
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0005770 late endosome
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0099073 mitochondrion-derived vesicle
Cellular Component GO:0030904 retromer complex
Cellular Component GO:0030906 retromer, cargo-selective complex
Cellular Component GO:0097422 tubular endosome
Molecular Function GO:0031748 D1 dopamine receptor binding
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0043653 mitochondrial fragmentation involved in apoptotic process
Biological Process GO:0099074 mitochondrion to lysosome vesicle-mediated transport
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:1902823 negative regulation of late endosome to lysosome transport
Biological Process GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane
Biological Process GO:0060161 positive regulation of dopamine receptor signaling pathway
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0090141 positive regulation of mitochondrial fission
Biological Process GO:0045732 positive regulation of protein catabolic process
Biological Process GO:1904377 positive regulation of protein localization to cell periphery
Biological Process GO:0036010 protein localization to endosome
Biological Process GO:1902950 regulation of dendritic spine maintenance
Biological Process GO:0031647 regulation of protein stability
Biological Process GO:2000331 regulation of terminal button organization
Biological Process GO:0042147 retrograde transport, endosome to Golgi
Biological Process GO:0045056 transcytosis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.