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Overview

Uniprot ID	A0A5G2R4Q8
Protein Name	RNA helicase aquarius
Gene Name	AQR
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
750	SGKGKKRKDADGEDE

Function

Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing

Protein Sequence

10 MTAPAQPKKI 20 VAPTVSQINA 30 EFVTQLACKY 40 WAPHIKKKSP 50 FDIKVIEDIY 60 EKEIVKSSQY 70 LENYLWMNYS 80 PEVSSKAYLM 90 SICCMVNEKF 100 RENVPAWETF 110 KKKPDHFPFF 120 FKCILKAALA 130 ETDGEFSLHE 140 QTVLLLFLDH 150 CFNSLEVDLI 160 RSQVQQLISL 170 PMWMGLQPAR 180 LELELKKTPK 190 LRKFWNLIKK 200 NDEKMDPEAR 210 EQAYQERKFL 220 SQLIQKFISV 230 LKSVPLSDPV 240 TMDKVHYCER 250 FIELMIDLEA 260 LLPTRRWFNT 270 ILDDSHLLVH 280 CYLSNLVHRE 290 EDGHLFSQLL 300 DMLKFYTGFE 310 INDQTGNALT 320 ENEMTTIHYD 330 RITSLQRAAF 340 AHFPELYDFA 350 LSNVAEVDTR 360 ESLVKFFGPL 370 SSNTLHQVAS 380 YLCLLPTLPK 390 AEDTTFDKEF 400 LLELLVSRHE 410 RRISQIQQLN 420 QMPLYPTEKI 430 IWDENIVPTE 440 YYSGEGCLAL 450 PKLNLQFLTL 460 HDYLLRNFNL 470 FRLESTYEIR 480 QDIEDSVSRM 490 KPWLSEYGGV 500 VFGGWARMAQ 510 PIVAFTVVEV 520 AKPNIGENWP 530 TRVRADVTIN 540 LNVRDHIKDE 550 WEGLRKHDVC 560 FLITVRPTKP 570 YGTKFDRRRP 580 FIEQVGLVYV 590 RGCEIQGMLD 600 DKGRVIEDGP 610 EPRPNLRGES 620 RTFRVFLDPN 630 QYQQDMTNTI 640 QNGAEDVYET 650 FNIIMRRKPK 660 ENNFKAVLET 670 IRNLMNTDCV 680 VPDWLHDIIL 690 GYGDPSSAHY 700 SKMPNQIATL 710 DFNDTFLSIE 720 HLKASFPGHN 730 VKVTVDDPAL 740 QIPPFRITFP 750 VRSGKGKKRK 760 DADGEDEDTE 770 EAKTLIVEPH 780 VIPNRGPYPY 790 NQPKRNTIQF 800 THTQIEAIRA 810 GMQPGLTMVV 820 GPPGTGKTDV 830 AVQIISNIYH 840 NFPEQRTLIV 850 THSNQALNQL 860 FEKIMALDID 870 ERHLLRLGHG 880 EEELETEKDF 890 SRYGRVNYVL 900 ARRIELLEEV 910 KRLQKSLGVP 920 GDASYTCETA 930 GYFFLYQVMS 940 RWEEYISKVK 950 NKGNTLPNVT 960 EVSTFFPFHE 970 YFANAPQPIF 980 KGRSYEEDME 990 IAEGCFRHIK 1000 KIFTQLEEFR 1010 ASELLRSGLD 1020 RSKYLLVKEA 1030 KIIAMTCTHA 1040 ALKRHDLVKL 1050 GFKYDNILME 1060 EAAQILEIET 1070 FIPLLLQNPQ 1080 DGFSRLKRWI 1090 MIGDHHQLPP 1100 VIKNMAFQKY 1110 SNMEQSLFTR 1120 FVRVGVPTVD 1130 LDAQGRARAS 1140 LCNLYNWRYK 1150 NLGNLPHVQL 1160 LPEFSTANAG 1170 LLYDFQLINV 1180 EDFQGVGESE 1190 PNPYFYQNLG 1200 EAEYVVALFM 1210 YMCLLGYPAD 1220 KISILTTYNG 1230 QKHLIRDIIN 1240 RRCGSNPLIG 1250 RPNKVTTVDR 1260 FQGQQNDYIL 1270 LSLVRTRAVG 1280 HLRDVRRLVV 1290 AMSRARLGLY 1300 IFARVSLFQN 1310 CFELTPAFSQ 1320 LTARPLHLHI 1330 IPTEPFPTSR 1340 KNGERPSHEV 1350 QIIKNMPQMA 1360 NFVYNMYMHL 1370 IQTTHHYHQT 1380 LLQLPPAMVE 1390 EGEEVQSQDT 1400 ELETEEEAMP 1410 APADIMPTLM 1420 DASSSQEASA 1430 SQTEPTSNET 1440 ETTSSQTGAD 1450 SNPEATPAES 1460 KITATAAGPV 1470 ATPAENNTPP 1480 DATSAPGETK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0071013	catalytic step 2 spliceosome
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016787	hydrolase activity
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0003724	RNA helicase activity
Biological Process	GO:0000398	mRNA splicing, via spliceosome

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.