Search Results

Overview

Uniprot ID	A0A5G2R519
Protein Name	AP-3 complex subunit delta-1
Gene Name	AP3D1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
176	IMYKVFLKYPESLRP

Function

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals

Protein Sequence

10 MALKMVKGSI 20 DRMFDKNLQD 30 LVRGIRNHKE 40 DEAKYISQCI 50 DEIKQELKQD 60 NIAVKANAVC 70 KLTYLQMLGY 80 DISWAAFNII 90 EVMSASKFTF 100 KRIGYLAASQ 110 CFHEGTDVIM 120 LTTNQIRKDL 130 SSPSQYDTGV 140 ALTGLSCFVT 150 PDLARDLAND 160 IMTLMSHTKP 170 YIRKKAVLIM 180 YKVFLKYPES 190 LRPAFPRLKE 200 KLEDPDPGVQ 210 SAAVNVICEL 220 ARRNPKNYLS 230 LAPLFFKLMT 240 SSTNNWVLIK 250 IIKLFGALTP 260 LEPRLGKKLI 270 EPLTNLIHST 280 SAMSLLYECV 290 NTVIAVLISL 300 SSGMPNHSAS 310 IQLCVQKLRI 320 LIEDSDQNLK 330 YLGLLAMSKI 340 LRTHPKSVQA 350 HKDLVLQCLD 360 DKDESIRLRA 370 LDLLYGMVSK 380 KNLMEIVKKL 390 MTHVDKAEGT 400 TYRDELLTKI 410 IDICSQSNYQ 420 HITNFEWYIS 430 ILVELTRLEG 440 TRHGHLIAAQ 450 MLDVAIRVKA 460 IRRFAVSQMS 470 ALLDSAHLVA 480 SSTQRNGICE 490 VLYAAAWICG 500 EFSEHLQDPQ 510 QTLEAMLRPK 520 VTTLPGHIQA 530 VYVQNVVKLY 540 AAILQQKEQA 550 ADAQAAQEVT 560 QLLVERLPQF 570 VQSADLEVQE 580 RASCILQLVK 590 HVQKLQAKDM 600 PVAEEVSALF 610 AGELNPVAPK 620 AQKKVPVPEG 630 LDLDAWINEP 640 LSDSESEDEK 650 PKAIFQDEEQ 660 RHAKQRPPEA 670 DEQELARRRE 680 ARKQEQANNP 690 FYIKSSPSPQ 700 KRYQDAPGVD 710 HIPVVQIDLS 720 VPLKVPGMPM 730 SDQYVKLEEE 740 RRHQQRLEKD 750 KRKKKRRERE 760 RRGTRRHSSL 770 HTESDEDIAP 780 AQRVDIVTEE 790 MPENALPSDE 800 DDKDPNDPYR 810 ALDIDLDKPL 820 ADSEKLPVQK 830 HRNAETPKSP 840 EKEDIPVIEK 850 KSKKPKKKEK 860 KHKEKEREKK 870 KKRKEAEKGE 880 DLDFWLSTTP 890 PVAAPAPEEP 900 RVNAAATAPE 910 EGLEEPREEV 920 QDADEDEHQE 930 PEKKTSKEKK 940 KKHKKDKEER 950 PKDKKKSKKK 960 TPPREGVAEP 970 VENGALDEEP 980 LPPMSSYCLL 990 AENSYIKMTY 1000 DVQGSLQKDS 1010 QVTVSVVLEN 1020 QSSSFLKSME 1030 LNVLDSLNAR 1040 LARPEGSSVH 1050 DGVPVPFQLP 1060 PGISNEAQFV 1070 FTIQSIVMAQ 1080 KLKGTLSFIA 1090 KNDEGSTHEK 1100 LDFKLHFTCT 1110 SYLVTTPCYS 1120 DAFAKLLESG 1130 DLSMSSIKVD 1140 GISMSFQNLL 1150 AKICFHHRFS 1160 VVERVDSCAS 1170 MYSRSIQGHH 1180 VCLLVKKVSP 1190 QEGPTQPFHS 1200 SALCLCSFEP 1210 CSGGCWPILR 1220 SSGLGTGTSP 1230 TKWGGIPSSS LL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030123	AP-3 adaptor complex
Cellular Component	GO:1904115	axon cytoplasm
Cellular Component	GO:0010008	endosome membrane
Cellular Component	GO:0000139	Golgi membrane
Cellular Component	GO:0098830	presynaptic endosome
Cellular Component	GO:0043195	terminal bouton
Biological Process	GO:0048490	anterograde synaptic vesicle transport
Biological Process	GO:0035646	endosome to melanosome transport
Biological Process	GO:0006896	Golgi to vacuole transport
Biological Process	GO:0098943	neurotransmitter receptor transport, postsynaptic endosome to lysosome
Biological Process	GO:0072657	protein localization to membrane
Biological Process	GO:0006623	protein targeting to vacuole
Biological Process	GO:0016182	synaptic vesicle budding from endosome
Biological Process	GO:0048499	synaptic vesicle membrane organization
Biological Process	GO:0140916	zinc ion import into lysosome

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.