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Overview

Uniprot ID	A0A5G2R5Q1
Protein Name	Nuclear valosin-containing protein-like
Gene Name	NVL
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
163	KTDPIPLKKTPARAS
729	ADRLAILKTITKNGT

Function

Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity

Protein Sequence

10 MKPRPARFVD 20 NKLKQRVIQY 30 LTSNRCGKYV 40 DTGVLASDLQ 50 RMYSIDYGRR 60 KRNAFRIQVE 70 KVFSIISSEK 80 ELKSLTELED 90 EHLAKRARHG 100 EEDNEYTESY 110 SDDDSNMEDY 120 PDPQSANHMN 130 SSLLSLYRKG 140 NSDSVSSTPE 150 MEQRETTVST 160 PRTTSKTDPI 170 PLKKTPARAS 180 EGGWFIDKTP 190 GGKKDSFFSD 200 LADEKNNHKK 210 PISEIEDSKD 220 SSLLESNKKR 230 KGRLNNKESK 240 RKKEDLQEVD 250 GEIEAVLQKK 260 AKARGLELQI 270 SNVKFEDVGG 280 NDTTLKEVCK 290 MLIHMRHPEV 300 YHHLGVIPPR 310 GVLLHGPPGC 320 GKTLLAHAIA 330 GELDLPILKV 340 AATEIVSGVS 350 GESEQKLREL 360 FEQAVSNAPC 370 ILFIDEIDAI 380 TPKREVASKD 390 MERRIVAQLL 400 TCMDDLNNMA 410 ATARVLVIGA 420 TNRPDSLDPA 430 LRRAGRFDRE 440 ICLGIPDEAS 450 RERILQTLCR 460 KLRLPETFRF 470 RHLAHLTPGF 480 VGADLMALCR 490 EAAVCAVNRV 500 LMKQQEQQKE 510 NPENEGLPSK 520 GGQEEGIGTE 530 PTSKGQALST 540 QDELQRLLGL 550 LRNQDPLSEE 560 QLQGLCIELN 570 DFIVALSSVQ 580 PSAKREGFVT 590 VPNVTWADIG 600 ALEDIREELT 610 MAILAPIRNP 620 DQFKALGLVT 630 PAGVLLAGPP 640 GCGKTLLAKA 650 VANESGLNFI 660 SVKGPELLNM 670 YVGESERAVR 680 QVFQRAKNSA 690 PCVIFFDEVD 700 ALCPRRSDII 710 DPAILRPGRL 720 DKTLFVGLPP 730 PADRLAILKT 740 ITKNGTKPPL 750 DADVNLEALA 760 GDLRCDCYTG 770 ADLSALVREA 780 SICALKQEMA 790 RHKSGNEKGE 800 LKISQKHFEE 810 AFKKVKSSIS 820 KEVSTPPPKK TKYSRGTAG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Biological Process	GO:0042254	ribosome biogenesis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.