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Overview

Uniprot IDA0A5G2R5U6
Protein NameCoatomer subunit gamma
Gene NameCOPG2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
187 KISYDVVKRWVNEAQ
827 QPCERSDKVPENKNS

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors

Protein Sequence

10 MPRAARRPRP 20 QPPPPAQLLG 30 ATSAGSGSNP 40 FRHLEKSAVL 50 QEARIFNETP 60 INPRRCLHIL 70 TKILYLLNQG 80 EYFGTTEATE 90 AFFAMTRLFQ 100 SNDQTLRRMC 110 YLTIKEMATI 120 SEDVIIVTSS 130 LTKDMTGKED 140 VYRGPAIRAL 150 CRITDGTMLQ 160 AIERYMKQAI 170 VDKVSSVSSS 180 ALVSSLHMMK 190 ISYDVVKRWV 200 NEAQEAASSD 210 NIMVQYHALG 220 VLYHLKKNDR 230 LAVSKMLNKF 240 TKCGLKSQFA 250 YCMLIRIASR 260 LLKENEEGHE 270 SPVFDFIESC 280 LRNKHEMVIY 290 EAASAIIHLP 300 NCSARELAPA 310 VSVLQLFCSS 320 PKPALRYAAV 330 RTLNKVAMKH 340 PSAVTACNLD 350 LENLITDSNR 360 SIATLAITTL 370 LKTGSESSVD 380 RLMKQISSFV 390 SEISDEFKVV 400 VVQAISALCQ 410 KYPRKHSVMM 420 TFLSNMLRDD 430 GGFEYKRAIV 440 DCIINIVEEN 450 PESKEAGLAH 460 LCEFIEDCEH 470 TVLATKILHL 480 LGKEGPRTPV 490 PSKYIRFIFN 500 RVVLENEAVR 510 AAAVSALAKF 520 GAQNENLLPS 530 ILVLLQRCMM 540 DTDDEVRDRA 550 TFYLNVLQQR 560 QMALNATYIF 570 NGLTVSVPGM 580 EKALHQYTLE 590 PSEKPFDMKS 600 IPLAMAPVFE 610 QKSEITLVAT 620 KPEKLAPSRQ 630 DIFQEQLAAI 640 PEFMNLGPLF 650 KSSEPVQLTE 660 AETEYFVRCV 670 KHMFTNHVVF 680 QFDCTNTLND 690 QLLEKVTVQV 700 EPSDSYEVLC 710 CIPAASLPYN 720 QPGICYTLVR 730 LPDDDSIAAA 740 GTFSCTMKFT 750 VRDCDPDTGV 760 PAEEGYDDEY 770 VLEDLEVTVS 780 DHIQKVLKPN 790 FAAAWEEVGD 800 TFEKEETFAL 810 SSTKTLEEAV 820 SNIITFLGMQ 830 PCERSDKVPE 840 NKNSHALYLA 850 GVYRGGCDLL 860 VRSRLALADG 870 VTMQVTVRSK 880 EGTPVDVILA SVG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030126 COPI vesicle coat
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0030426 growth cone
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0006891 intra-Golgi vesicle-mediated transport
Biological Process GO:0006886 intracellular protein transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.