Search Results
Overview
| Uniprot ID | A0A5G2R5Z1 |
|---|---|
| Protein Name | DNA topoisomerase 2 |
| Gene Name | TOP2B |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1023 | DHMGCLKKYETVQDI |
| 197 | FTVETACKEYKHSFK |
| 264 | YDLAGSCKGVKVMFN |
| 291 | VDLYVKDKLDETGVA |
| 438 | KAQTQLNKKCSSVKY |
| 740 | GFKPGQRKVLFTCFK |
Function
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand
Protein Sequence
10
MAKAGGGGAG
20
VGGDAALTWV
30
NNAAKKEESE
40
TANKNDSSKK
50
LSVERVYQKK
60
TQLEHILLRP
70
DTYIGSVEPL
80
TQLMWVYDED
90
VGMNCREVTF
100
VPGLYKIFDE
110
ILVNAADNKQ
120
RDKNMTCIKV
130
SIDPESNIIS
140
IWNNGKGIPV
150
VEHKVEKVYV
160
PALIFGQLLT
170
SSNYDDDEKK
180
VTGGRNGYGA
190
KLCNIFSTKF
200
TVETACKEYK
210
HSFKQTWMNN
220
MMKTSEAKIK
230
HFDGEDYTCI
240
TFQPDLAKFK
250
MEKLDKDIVA
260
LMTRRAYDLA
270
GSCKGVKVMF
280
NGKKLPVNGF
290
RSYVDLYVKD
300
KLDETGVALK
310
VIHELANERW
320
DVCLTLSEKG
330
FQQISFVNSI
340
ATTKGGRHVD
350
YVVDQVVGKL
360
IEVVKKKNKA
370
GVSVKPFQVK
380
NHIWVFINCL
390
IENPTFDSQT
400
KENMTLQPKS
410
FGSKCQLSEK
420
FFKAASNCGI
430
VESILNWVKF
440
KAQTQLNKKC
450
SSVKYSKIKG
460
IPKLDDANDA
470
GGKHSLECTL
480
ILTEGDSAKS
490
LAVSGLGVIG
500
RDRYGVFPLR
510
GKILNVREAS
520
HKQIMENAEI
530
NNIIKIVGLQ
540
YKKSYDDAES
550
LKTLRYGKIM
560
IMTDQDQDGS
570
HIKGLLINFI
580
HHNWPSLLKH
590
GFLEEFITPI
600
VKASKNKQEL
610
AFYSIPEFDE
620
WKKHIENQKA
630
WKIKYYKGLG
640
TSTAKEAKEY
650
FADMERHRIL
660
FRYAGPEDDA
670
AITLAFSKKK
680
IDDRKEWLTN
690
FMEDRRQRRL
700
HGLPEQFLYG
710
TATKHLTYND
720
FINKELILFS
730
NSDNRSIPSL
740
VDGFKPGQRK
750
VLFTCFKRND
760
KREVKVAQLA
770
GSVAEMSAYH
780
HGEQALMMTI
790
VNLAQNFVGS
800
NNINLLQPIG
810
QFGTRLHGGK
820
DAASPRYIFT
830
MLSSLARLLF
840
PAVDDNLLKF
850
LYDDNQRVEP
860
EWYIPIIPMV
870
LINGAEGIGT
880
GWACKLPNYD
890
AREIVNNVRR
900
MLDGLDPHPM
910
LPNYKNFKGT
920
IQELGQNQYA
930
VSGEIFVVDR
940
NTVEITELPV
950
RTWTQVYKEQ
960
VLEPMLNGTD
970
KTPALISDYK
980
EYHTDTTVKF
990
VVKMTEEKLA
1000
QAEAAGLHKV
1010
FKLQTTLTCN
1020
SMVLFDHMGC
1030
LKKYETVQDI
1040
LKEFFDLRLS
1050
YYGLRKEWLV
1060
GMLGAESTKL
1070
NNQARFILEK
1080
IQGKITIENR
1090
SKKDLIQMLV
1100
QRGYESDPVK
1110
AWKEAQEKAA
1120
EEEETQNQHD
1130
DSSSDSGTPS
1140
GPDFNYILNM
1150
SLWSLTKEKV
1160
EELIKQRDAK
1170
GREVNDLKRK
1180
SPSDLWKEDL
1190
AAFVEELDKV
1200
EAQEREDVLA
1210
GMAGKAIKGK
1220
IGKPKVKKLQ
1230
LEETMPSPFG
1240
RRIVPEITAM
1250
KADASKKLLK
1260
KKKGDLDTTA
1270
VKVEFDEEFS
1280
GTPVEGTGEE
1290
ALIQSAPINK
1300
GPKPKREKKE
1310
PGTRVRKTPT
1320
SSGKPSAKKV
1330
KKRNPWSDDE
1340
SKSESDLEET
1350
EPVVIPRDSL
1360
LRRAAAERPK
1370
YTFDFSEEED
1380
EDADDDEDNN
1390
DLEELKVKAS
1400
PVTNDGEDES
1410
VPSDGLDKDE
1420
YTFSPGKSKA
1430
TPEKSSHDKK
1440
SQDFGNLFSF
1450
PSYSQKSEDD
1460
SAKFDSNEED
1470
SASVFSPSFG
1480
LKQTEKVPSK
1490
TVAAKKGKPS
1500
LDTTPKPKRT
1510
PKQKKVETIN
1520
SDSDSEFGIP
1530
KKTAPKVGKG
1540
RGAKKRKASG
1550
SENEGDYNPG
1560
RRTSKTTSKK
1570
PKKTSFDQDS
1580
DVDLFPSDFT
1590
AEPPSLPRTG
1600
RARKEVKYFA
1610
ESDEEEDVDF
AMFN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003918 | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006265 | DNA topological change |
| Biological Process | GO:0000712 | resolution of meiotic recombination intermediates |
| Biological Process | GO:0000819 | sister chromatid segregation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.