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Overview

Uniprot IDA0A5G2R5Z1
Protein NameDNA topoisomerase 2
Gene NameTOP2B
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1023 DHMGCLKKYETVQDI
197 FTVETACKEYKHSFK
264 YDLAGSCKGVKVMFN
291 VDLYVKDKLDETGVA
438 KAQTQLNKKCSSVKY
740 GFKPGQRKVLFTCFK

Function

Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand

Protein Sequence

10 MAKAGGGGAG 20 VGGDAALTWV 30 NNAAKKEESE 40 TANKNDSSKK 50 LSVERVYQKK 60 TQLEHILLRP 70 DTYIGSVEPL 80 TQLMWVYDED 90 VGMNCREVTF 100 VPGLYKIFDE 110 ILVNAADNKQ 120 RDKNMTCIKV 130 SIDPESNIIS 140 IWNNGKGIPV 150 VEHKVEKVYV 160 PALIFGQLLT 170 SSNYDDDEKK 180 VTGGRNGYGA 190 KLCNIFSTKF 200 TVETACKEYK 210 HSFKQTWMNN 220 MMKTSEAKIK 230 HFDGEDYTCI 240 TFQPDLAKFK 250 MEKLDKDIVA 260 LMTRRAYDLA 270 GSCKGVKVMF 280 NGKKLPVNGF 290 RSYVDLYVKD 300 KLDETGVALK 310 VIHELANERW 320 DVCLTLSEKG 330 FQQISFVNSI 340 ATTKGGRHVD 350 YVVDQVVGKL 360 IEVVKKKNKA 370 GVSVKPFQVK 380 NHIWVFINCL 390 IENPTFDSQT 400 KENMTLQPKS 410 FGSKCQLSEK 420 FFKAASNCGI 430 VESILNWVKF 440 KAQTQLNKKC 450 SSVKYSKIKG 460 IPKLDDANDA 470 GGKHSLECTL 480 ILTEGDSAKS 490 LAVSGLGVIG 500 RDRYGVFPLR 510 GKILNVREAS 520 HKQIMENAEI 530 NNIIKIVGLQ 540 YKKSYDDAES 550 LKTLRYGKIM 560 IMTDQDQDGS 570 HIKGLLINFI 580 HHNWPSLLKH 590 GFLEEFITPI 600 VKASKNKQEL 610 AFYSIPEFDE 620 WKKHIENQKA 630 WKIKYYKGLG 640 TSTAKEAKEY 650 FADMERHRIL 660 FRYAGPEDDA 670 AITLAFSKKK 680 IDDRKEWLTN 690 FMEDRRQRRL 700 HGLPEQFLYG 710 TATKHLTYND 720 FINKELILFS 730 NSDNRSIPSL 740 VDGFKPGQRK 750 VLFTCFKRND 760 KREVKVAQLA 770 GSVAEMSAYH 780 HGEQALMMTI 790 VNLAQNFVGS 800 NNINLLQPIG 810 QFGTRLHGGK 820 DAASPRYIFT 830 MLSSLARLLF 840 PAVDDNLLKF 850 LYDDNQRVEP 860 EWYIPIIPMV 870 LINGAEGIGT 880 GWACKLPNYD 890 AREIVNNVRR 900 MLDGLDPHPM 910 LPNYKNFKGT 920 IQELGQNQYA 930 VSGEIFVVDR 940 NTVEITELPV 950 RTWTQVYKEQ 960 VLEPMLNGTD 970 KTPALISDYK 980 EYHTDTTVKF 990 VVKMTEEKLA 1000 QAEAAGLHKV 1010 FKLQTTLTCN 1020 SMVLFDHMGC 1030 LKKYETVQDI 1040 LKEFFDLRLS 1050 YYGLRKEWLV 1060 GMLGAESTKL 1070 NNQARFILEK 1080 IQGKITIENR 1090 SKKDLIQMLV 1100 QRGYESDPVK 1110 AWKEAQEKAA 1120 EEEETQNQHD 1130 DSSSDSGTPS 1140 GPDFNYILNM 1150 SLWSLTKEKV 1160 EELIKQRDAK 1170 GREVNDLKRK 1180 SPSDLWKEDL 1190 AAFVEELDKV 1200 EAQEREDVLA 1210 GMAGKAIKGK 1220 IGKPKVKKLQ 1230 LEETMPSPFG 1240 RRIVPEITAM 1250 KADASKKLLK 1260 KKKGDLDTTA 1270 VKVEFDEEFS 1280 GTPVEGTGEE 1290 ALIQSAPINK 1300 GPKPKREKKE 1310 PGTRVRKTPT 1320 SSGKPSAKKV 1330 KKRNPWSDDE 1340 SKSESDLEET 1350 EPVVIPRDSL 1360 LRRAAAERPK 1370 YTFDFSEEED 1380 EDADDDEDNN 1390 DLEELKVKAS 1400 PVTNDGEDES 1410 VPSDGLDKDE 1420 YTFSPGKSKA 1430 TPEKSSHDKK 1440 SQDFGNLFSF 1450 PSYSQKSEDD 1460 SAKFDSNEED 1470 SASVFSPSFG 1480 LKQTEKVPSK 1490 TVAAKKGKPS 1500 LDTTPKPKRT 1510 PKQKKVETIN 1520 SDSDSEFGIP 1530 KKTAPKVGKG 1540 RGAKKRKASG 1550 SENEGDYNPG 1560 RRTSKTTSKK 1570 PKKTSFDQDS 1580 DVDLFPSDFT 1590 AEPPSLPRTG 1600 RARKEVKYFA 1610 ESDEEEDVDF AMFN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0006265 DNA topological change
Biological Process GO:0000712 resolution of meiotic recombination intermediates
Biological Process GO:0000819 sister chromatid segregation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.