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Overview

Uniprot ID	A0A5G2R5Z3
Protein Name	Cell surface glycoprotein MUC18
Gene Name	MCAM
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
148	RIFLCQGKRPRSQEH

Function

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration

Protein Sequence

10 MGTSGLICAF 20 LLASCCCCRR 30 VAGVPGEAEK 40 PAPELLEVEV 50 GGTALLKCGP 60 SHSQSNFSHV 70 DWFSVSAPEE 80 GSRGGRQRPR 90 PSRSPRTLTS 100 SPQVHKEKPT 110 LIFRVRQGQG 120 QSEPGEYQHR 130 LHLQDKGTTL 140 ALTHITPHDE 150 RIFLCQGKRP 160 RSQEHRVQLR 170 VYKAPEEPTI 180 QVNPLGISVN 190 SEEPEEVATC 200 VGRNGYPLPQ 210 VIWYKNGRPL 220 KEEKNRVQIQ 230 SFQIVESSGL 240 YTLQSVLKAQ 250 LAKEDKDAQF 260 YCELSYRLPS 270 GNHMKESPEV 280 MVPVFYPAER 290 VWLEVEPEGM 300 LKEGDRVEIR 310 CLADGNPPPH 320 FSISKQNLST 330 KEMEEESTDD 340 NGILVLEPAQ 350 KEHSGLYECQ 360 GLDLETTVSL 370 LSDQQELLVN 380 YVSDVRVSPA 390 APESQEGSSL 400 TLTCEAESNQ 410 DLEFQWLREK 420 TGKVLERGPV 430 LQLRNLKREE 440 GGGYRCVASA 450 PSVPGLNRTQ 460 LVNVAIFGSP 470 WMTLRERKIR 480 VKENTMLNLS 490 CEASGHPRPS 500 IIWNVDGTAS 510 EQDQDPQTVL 520 SILSVLVTPE 530 LLETGAKCVA 540 SNPLGENVTS 550 IILELDSNRT 560 NSLSTSTFSP 570 PARANSTSTE 580 RKLPEPESKG 590 VVIVAVTVCV 600 LVLAVLGAVL 610 YFFYKKGKLP 620 CGRSGKQEIT 630 LPPSRKSEFV 640 VEVKSDKLPE 650 EMGLLQGSNG 660 DKRAPGDQGE KYIDLRH

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0009897	external side of plasma membrane
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005886	plasma membrane
Biological Process	GO:0001525	angiogenesis
Biological Process	GO:0007155	cell adhesion
Biological Process	GO:0003094	glomerular filtration
Biological Process	GO:0061042	vascular wound healing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.