Search Results
Overview
| Uniprot ID | A0A5G2R6E0 |
|---|---|
| Protein Name | LIM and senescent cell antigen-like-containing domain protein |
| Gene Name | LIMS1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 193 | EKARGLGKYICQKCH |
| 198 | LGKYICQKCHAIIDE |
| 227 | FNCANCGKELTADAR |
| 248 | YCLPCHDKMGVPICG |
| 282 | VEHFVCAKCEKPFLG |
| 285 | FVCAKCEKPFLGHRH |
| 358 | KFVEFDMKPVCKKCY |
| 367 | VCKKCYEKFPLELKK |
| 373 | EKFPLELKKRLKKLA |
| 378 | ELKKRLKKLAETLGR |
| 51 | HSDLKVYKEFCDFYA |
Function
Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration
Protein Sequence
10
MALPGPRPAI
20
IPEDEEVPQA
30
ARNGVHRAPG
40
GEDERAVSRP
50
QRRHSDLKVY
60
KEFCDFYAKF
70
NMANALANAS
80
CERCRGGFAP
90
AEKIVNSNGE
100
LYHEQCFVCA
110
QCFQQFPEGL
120
FYEFEGRKYC
130
EHDFQMLFAP
140
CCHQCGEFII
150
GRVIKAMNNS
160
WHPECFRCDL
170
CQEVLADIGF
180
VKNAGRHLCR
190
PCHNREKARG
200
LGKYICQKCH
210
AIIDEQPLIF
220
KNDPYHPDHF
230
NCANCGKELT
240
ADARELKGEL
250
YCLPCHDKMG
260
VPICGACRRP
270
IEGRVVNAMG
280
KQWHVEHFVC
290
AKCEKPFLGH
300
RHYERKGLAY
310
CETHYNQLFG
320
DVCFHCNRVI
330
EGDVVSALNK
340
AWCVSCFACS
350
TCNTKLTLKN
360
KFVEFDMKPV
370
CKKCYEKFPL
380
ELKKRLKKLA
ETLGRK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0009967 | positive regulation of signal transduction |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.