Overview
| Uniprot ID | A0A5G2R6I6 |
|---|
| Protein Name | Nucleolar protein 58 |
|---|
| Gene Name | NOP58 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 202 |
TYCKCLQKVGDRKNY |
| 29 |
KEFETPEKANKVVKL |
| 315 |
VQILGAEKALFRALK |
| 403 |
RKISGTGKALAKAEK |
| 433 |
STLPTFSKKRRIEQV |
| 73 |
KVLKKIVKEAHEPLA |
| 85 |
PLAVADAKLGGVIKE |
| 91 |
AKLGGVIKEKLNLSC |
Function
Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs)
Protein Sequence
10
MYTCTLRVLN
20
EKKLQEVDSL
30
WKEFETPEKA
40
NKVVKLKHFE
50
KFQDTAEALA
60
AFTALMEGKI
70
NKQLKKVLKK
80
IVKEAHEPLA
90
VADAKLGGVI
100
KEKLNLSCIH
110
SPVVNELMRG
120
IRSQMDGLIP
130
GVEPREMAAM
140
CLGLAHSLSR
150
YRLKFSADKV
160
DTMIVQAISL
170
LDDLDKELNN
180
YIMRCREWYG
190
WHFPELGKII
200
SDNLTYCKCL
210
QKVGDRKNYA
220
SAKLSELLPE
230
EVEAEVKAAA
240
EISMGTEVSE
250
EDICNILHLC
260
TQVIEISEYR
270
TQLYEYLQNR
280
MMAIAPNVTV
290
MVGELVGARL
300
IAHAGSLLNL
310
AKHAASTVQI
320
LGAEKALFRA
330
LKSRRDTPKY
340
GLIYHASLVG
350
QTSPKHKGKI
360
SRMLAAKTVL
370
AIRYDAFGED
380
SSSAMGVENR
390
AKLEARLRTL
400
EDRGIRKISG
410
TGKALAKAEK
420
YEHKSEVKTY
430
DPSGDSTLPT
440
FSKKRRIEQV
450
DKEDEVIEKK
460
AKKAKVKIKA
470
LLVCEHLGKP
480
TVSQAFVKWM
490
TRKTQGDKIQ
500
QLLPSGSLQS
ELQTS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031428 |
box C/D methylation guide snoRNP complex |
| Cellular Component |
GO:0032040 |
small-subunit processome |
| Molecular Function |
GO:0030515 |
snoRNA binding |
| Biological Process |
GO:0042254 |
ribosome biogenesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.