Search Results
Overview
| Uniprot ID | A0A5G2R6P1 |
|---|---|
| Protein Name | SPARC |
| Gene Name | SPARC |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 126 | SCHFFATKCTLEGTK |
| 137 | EGTKKGHKLHLDYIG |
| 188 | NNNLLTEKQKLRVKK |
| 201 | KKIHENEKRLEGDHP |
Function
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity
Protein Sequence
10
MRAWIFFLLC
20
LAGKALAAPQ
30
QEALPDETEV
40
VEETVAEVPV
50
GANPVQVEVG
60
EFDDGAEEAE
70
EEVVAENPCQ
80
NHHCKHGKVC
90
ELDENNSPMC
100
VCQDPTSCPA
110
PIGEFEKVCS
120
NDNKTFDSSC
130
HFFATKCTLE
140
GTKKGHKLHL
150
DYIGPCKYIP
160
PCLDSELTEF
170
PLRMRDWLKN
180
VLVTLYERDE
190
NNNLLTEKQK
200
LRVKKIHENE
210
KRLEGDHPVE
220
LLARDFEKNY
230
NMYIFPVHWQ
240
FGQLDQHPID
250
GYLSHTELAP
260
LRAPLIPMEH
270
CTTRFFQTCD
280
LDNDKYIALD
290
EWAGCFGIKE
QDIDKDLVI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0031092 | platelet alpha granule membrane |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005518 | collagen binding |
| Biological Process | GO:0016525 | negative regulation of angiogenesis |
| Biological Process | GO:0001937 | negative regulation of endothelial cell proliferation |
| Biological Process | GO:0010595 | positive regulation of endothelial cell migration |
| Biological Process | GO:0022604 | regulation of cell morphogenesis |
| Biological Process | GO:0050807 | regulation of synapse organization |
| Biological Process | GO:0048752 | semicircular canal morphogenesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.