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Overview

Uniprot ID	A0A5G2R6Q1
Protein Name	Inter-alpha-trypsin inhibitor heavy chain H3
Gene Name	ITIH3
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
129	DKTAGLVKASGRKLE
227	KKGHVSFKPSLDQQR

Function

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes

Protein Sequence

10 MASARWPCLI 20 LALLSSLAVS 30 GFPRSPSRQL 40 GKRSLPGAVV 50 NGIEVYSTKV 60 SCKVTSRFAH 70 NVVTTRAVNH 80 ADTAKEVSFD 90 VELPKTAFIT 100 NFTLTIDGVT 110 YPGNVKEKEV 120 AKKQYEKAVS 130 QDKTAGLVKA 140 SGRKLEKFTV 150 SVNVAAGSKV 160 TFELTYEELL 170 KRHKGKYEMY 180 LKVQPKQLVK 190 HFEITADIFE 200 PQGISTLDAE 210 ASFITNDLLG 220 SALTKSFSGK 230 KGHVSFKPSL 240 DQQRSCPTCT 250 DSLLKGDFII 260 TYDVNRESPA 270 NVQIVNGYFV 280 HFFAPQGLPV 290 VPKNVVFVID 300 VSGSMYGRKM 310 EQTKDALLKI 320 LDDIKEDDYL 330 NFVLFSGDVT 340 TWKDSLVQAT 350 PENIQKAREF 360 VRNIRDQGSV 370 SKPEKIQENV 380 RNAIGGKFPL 390 YNLGFGNNLN 400 YNFLESMALE 410 NHGLARRIYE 420 DSDANLQLQG 430 FYEEVANPLL 440 TSVEVGYPEN 450 AIQDLTQNTY 460 QHFYDGSEIV 470 VAGRLADEDM 480 NSFRADVKGH 490 GAINDLTFTE 500 EVDMKEMEEA 510 LKERDYIFGN 520 YIERLWAYLT 530 IEQLLEKRKN 540 AQGKEKETLT 550 AQALDLSLKY 560 HFVTPLTSMV 570 VTKPEDNENQ 580 TAIADKPGEE 590 PVDAVTPSTA 600 YLTSYQPPVT 610 PYYYVDGDPH 620 FIIQVPEKDD 630 AICFNIDEDP 640 GTVLRLIQDP 650 VTGLTVNGQI 660 IGEKRSSQDS 670 QPRKTYFGKL 680 GIANAHLDFR 690 IEVTPERITL 700 WNGAAQSTFS 710 WLDTVMVTQD 720 GLSVMINKKN 730 MVVSFGDGAT 740 FVVVLHQVWK 750 KQPNHHDFLG 760 FYVVDSHRMS 770 TQTHGLLGQF 780 FHPFDFKVSD 790 IHPGSDPTKP 800 DATMVVKNHR 810 LTVTRGSQKD 820 YRKDASIGVK 830 VACWFVHDNG 840 QGLIDGIHSD YIVPDLF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005576	extracellular region
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity
Biological Process	GO:0030212	hyaluronan metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.