Search Results
Overview
| Uniprot ID | A0A5G2R6R2 |
|---|---|
| Protein Name | Protein disulfide-isomerase A6 |
| Gene Name | PDIA6 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 108 | IKIFGSNKNRPEDYQ |
| 150 | GGGYSSGKQGRSEGS |
| 160 | RSEGSGKKDVIELTD |
| 208 | AAAATEVKEQTKGKV |
| 216 | EQTKGKVKLAAVDAT |
| 241 | IRGFPTIKIFQKGES |
| 245 | PTIKIFQKGESPVDY |
| 368 | AINARKMKFALLKGS |
| 66 | QRLTPEWKKVATALK |
| 67 | RLTPEWKKVATALKD |
| 73 | KKVATALKDVVKVGA |
| 77 | TALKDVVKVGAVDAD |
| 85 | VGAVDADKHQSLGGQ |
Function
May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin
Protein Sequence
10
MARLVLGLMS
20
CTLFVAVNGL
30
YSSSDDVIEL
40
TPSNFNREVI
50
QSDSLWLVEF
60
YAPWCGHCQR
70
LTPEWKKVAT
80
ALKDVVKVGA
90
VDADKHQSLG
100
GQYGVQGFPT
110
IKIFGSNKNR
120
PEDYQGGRTG
130
EAIVDAALSA
140
LRQLVKDRLG
150
GRGGGYSSGK
160
QGRSEGSGKK
170
DVIELTDDTF
180
DKNVLDSEDV
190
WMVEFYAPWC
200
GHCKNLEPEW
210
AAAATEVKEQ
220
TKGKVKLAAV
230
DATVNQVLAS
240
RYGIRGFPTI
250
KIFQKGESPV
260
DYDGGRTRSD
270
IVTRALDLFS
280
DNAPPPELLE
290
IISEDVAKKS
300
CEEHQLCVVA
310
VLPHILDTGA
320
AGRNSYLEVL
330
LKLADKYKKK
340
MWGWLWTEAG
350
AQTELEHALG
360
IGGFGYPAMA
370
AINARKMKFA
380
LLKGSFSEQG
390
INEFLRELSF
400
GRGSTAPVGG
410
GAFPAISTRE
420
PWDGKDGEVS
430
PATREPGDGK
440
DGQASPATRE
450
PWDGKDGQAS
460
PATREPGDGK
470
DGEASPAEPR
480
GQDASRLWLS
490
FLASLGPEAG
500
CEPGLCIRAA
510
PRAGPAVAPP
520
GPRGLLLSSS
530
SAPLPPATPQ
540
AKAPGSCSPG
550
HSPQAERFST
560
WREAQRGHFE
570
VSLDSRTLPS
580
GLERPTSVAP
590
GVCPRDDGRS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0003756 | protein disulfide isomerase activity |
| Molecular Function | GO:0015035 | protein-disulfide reductase activity |
| Biological Process | GO:0034976 | response to endoplasmic reticulum stress |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.