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Overview

Uniprot IDA0A5G2R6V4
Protein NamePyrroline-5-carboxylate reductase
Gene NamePYCR1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
172 TISSIEKKLTAFQPA
181 TAFQPAPKVIRCMTN
356 KTVLDKVKLDSPAGA
372 GAPPGHSKLLPRSLA

Function

No function data available.

Protein Sequence

10 MGGGTGAGER 20 WTSWNGGGPS 30 VGDGVAKLGT 40 ARLTFCAGSC 50 PFVCPAAVPR 60 AGASCEGSGP 70 RPPDTMSVGF 80 IGAGQLAFAL 90 AKGFTAAGVL 100 AAHKIMASSP 110 DMDLATVSAL 120 RKMGVNLTPH 130 NKEAVQHSDV 140 LFLAVKPHII 150 PFILDEIAPD 160 IETRHIVVSC 170 AAGVTISSIE 180 KKLTAFQPAP 190 KVIRCMTNTP 200 VVVRQGATVY 210 ATGTHAQVED 220 GRLLEQLMGS 230 VGFCTEVEED 240 LIDAVTGLSG 250 SGPAYAFTAL 260 DALADGGVKM 270 GLPRRLAVRL 280 GAQALLGAAK 290 MLLDSEQHPG 300 QLKDNVCSPG 310 GATIHALHVL 320 ESGGFRSLLI 330 NAVEASCIRT 340 RELQSMADQE 350 EVSPAAIKKT 360 VLDKVKLDSP 370 AGASGAPPGH 380 SKLLPRSLAP AGKSD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:1902792 pyrroline-5-carboxylate reductase complex
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0004735 pyrroline-5-carboxylate reductase activity
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0055129 L-proline biosynthetic process
Biological Process GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
Biological Process GO:0051881 regulation of mitochondrial membrane potential

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.