Search Results
Overview
| Uniprot ID | A0A5G2R744 |
|---|---|
| Protein Name | Protein phosphatase methylesterase 1 |
| Gene Name | PPME1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 294 | LLFLQTKKDHPYTWR |
| 30 | GGSQSGAKMRMGPGR |
Function
Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme
Protein Sequence
10
MSALEKSMHL
20
GRLPSRPPLP
30
GSGGSQSGAK
40
MRMGPGRKRD
50
FSPVPWSQYF
60
ESMEDVEVEN
70
ETGKDTFRVY
80
KSGSEGPVLL
90
LLHGGGHSAL
100
SWAVFTAAII
110
SRVQCRIVAL
120
DLRGHGETKV
130
KNSEDLSAET
140
MAKDVGNVVE
150
AMYGDLPPPI
160
MLIGHSMGGA
170
IAVHTSSNLV
180
PSLLGLCMID
190
VVEGTAMDAL
200
NSMQNFLRGR
210
PKTFKSLENA
220
IEWSVKSGQI
230
RNLESARVSM
240
VGQVKQCEGI
250
TSPEGSKSIV
260
EGIIEEEEED
270
EEGSESVNKR
280
KKEDDMEGLP
290
SETQHLLLFL
300
QTKKDHPYTW
310
RIELAKTEKY
320
WDGWFRGLSN
330
LFLSCPIPKL
340
LLLAGVDRLD
350
KDLTIGQMQG
360
KFQMQVLPQC
370
GHAVHEDAPD
380
KVAEAVATFL
390
IRHRFAEPIG
GFQCVFPGC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016604 | nuclear body |
| Molecular Function | GO:0106222 | lncRNA binding |
| Molecular Function | GO:0051723 | protein methylesterase activity |
| Molecular Function | GO:0051721 | protein phosphatase 2A binding |
| Molecular Function | GO:0004864 | protein phosphatase inhibitor activity |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.